Table 2.
Epigenome-wide Significant Associations with MLD and RES score among AA mothers (n=147).
| CpG Sites | Chr | bp | Gene | Exposure | Beta | SE | T-stat | P-value after GCa | FDR adjusted p-valueb |
|---|---|---|---|---|---|---|---|---|---|
| cg09437479 | 16 | 78539954 | WWOX | RES | -1.73E-03 | 7.47E-04 | -2.32 | 3.56E-02 | 0.994 |
| MLD | -1.13E-02 | 1.88E-03 | -6.03 | 6.25E-08 | 0.031 | ||||
| cg16143945 | 3 | 126168382 | ZXDC | RES | 5.96E-04 | 1.36E-04 | 4.38 | 1.02E-04 | 0.766 |
| MLD | 2.27E-03 | 3.79E-04 | 6.00 | 7.30E-08 | 0.031 | ||||
| cg03317714 | 11 | 69912795 | LOC101928443 | RES | -1.85E-03 | 5.65E-04 | -3.28 | 3.16E-03 | 0.941 |
| MLD | -8.69E-03 | 1.49E-03 | -5.85 | 1.43E-07 | 0.035 | ||||
| cg19958721 | 2 | 144455439 | ARHGAP15 | RES | -1.45E-03 | 5.67E-04 | -2.56 | 2.07E-02 | 0.981 |
| MLD | -8.23E-03 | 1.43E-03 | -5.74 | 2.28E-07 | 0.035 | ||||
| cg05711042 | 5 | 150913871 | FAT2 | RES | -2.59E-03 | 6.59E-04 | -3.93 | 4.50E-04 | 0.823 |
| MLD | -1.14E-02 | 2.00E-03 | -5.69 | 2.88E-07 | 0.035 | ||||
| cg02578462 | 7 | 2028754 | MAD1L1 | RES | -1.59E-03 | 4.42E-04 | -3.60 | 1.24E-03 | 0.888 |
| MLD | -6.49E-03 | 1.14E-03 | -5.69 | 2.89E-07 | 0.035 | ||||
| cg07726178 | 7 | 110748868 | LRRN3; IMMP2L | RES | -1.62E-03 | 4.10E-04 | -3.95 | 4.27E-04 | 0.808 |
| MLD | -6.58E-03 | 1.16E-03 | -5.68 | 2.94E-07 | 0.035 | ||||
| cg15209133 | 14 | 70020151 | RES | 2.21E-03 | 7.21E-04 | 3.06 | 5.76E-03 | 0.957 | |
| MLD | 1.13E-02 | 1.99E-03 | 5.66 | 3.32E-07 | 0.035 | ||||
| cg04928761 | 10 | 108756503 | SORCS1 | RES | -3.16E-03 | 1.01E-03 | -3.13 | 4.87E-03 | 0.954 |
| MLD | -1.46E-02 | 2.62E-03 | -5.59 | 4.49E-07 | 0.042 |
a
GC: genomic control;
b
FDR adjustment applied after GC approach