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. Author manuscript; available in PMC: 2018 Apr 4.
Published in final edited form as: Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4):a028522. doi: 10.1101/cshperspect.a028522

Figure 3. IL-17RA/RB signaling.

Figure 3

Upon IL-17E binding to its receptor, homotypic interactions between the SEFIR domains in the receptor and in the adapter Act1/CIKS are established. This leads to the recruitment of TRAF6, activating the MAPK and NF-κB signaling pathways. In turn, Act1 can recruit TRAF4, which activates the E3 ligase SMURF2. This leads to the ubiquitylation and subsequent degradation of the inhibitor DAZAP2, amplifying IL-17E-mediated signaling. In addition, IL-17RB can elicit STAT5 activation in an Act1-independent manner.