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. Author manuscript; available in PMC: 2017 Dec 6.
Published in final edited form as: J Org Chem. 2017 Oct 13;82(23):11961–11980. doi: 10.1021/acs.joc.7b02088

Figure 12.

Figure 12

Structure of bleomycin A2, NMR structure of bleomycin bound to a DNA cleavage site (full deoxyoligonucleotide and bleomycin disaccharide removed for clarity), key H-bonding role the pyrimidine C4 amine plays in guanine recognition, and role the minor groove guanine C2 amine plays in the recognition of bleomycin.