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. Author manuscript; available in PMC: 2017 Dec 6.
Published in final edited form as: J Org Chem. 2017 Oct 13;82(23):11961–11980. doi: 10.1021/acs.joc.7b02088

Figure 3.

Figure 3

Vancomycin analog that contains a single atom change in the binding pocket, reinstating activity against vancomycin-resistant bacteria, and two peripheral modifications that add two additional independent mechanisms of action.