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. Author manuscript; available in PMC: 2017 Dec 6.
Published in final edited form as: J Org Chem. 2017 Oct 13;82(23):11961–11980. doi: 10.1021/acs.joc.7b02088

Figure 4.

Figure 4

Structure of [L-Dap2]ramoplanin A2 aglycon and a single heavy atom exchange in 49-membered macrocycle that substantially improves hydrolytic stability shown to limit the clinical use of ramoplanin.