Table A1.
Joint genotype probabilities for two siblings
X1 | X2 | P(X1, X2) |
---|---|---|
AA | AA | 0.25 p2 (1 + p)2 |
AA | Aa | 0.5 p2 (1 − p2) |
AA | aa | 0.25 p2 (1 − p)2 |
Aa | AA | 0.5 p2 (1 − p2) |
Aa | Aa | p(1 − p)(1 + p(1 − p)) |
Aa | aa | p(1 − p)2(1 − 0.5 p) |
aa | AA | 0.25 p2 (1 − p)2 |
aa | Aa | p(1 − p)2(1 − 0.5 p) |
aa | aa | (1 − p)2(1 − 0.5 p)2 |
p is the population frequency of disease susceptibility allele A.