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. Author manuscript; available in PMC: 2018 Oct 12.
Published in final edited form as: Medchemcomm. 2017 Oct 12;8(11):2040–2049. doi: 10.1039/c7md00310b

Scheme 1.

Scheme 1

Synthesis of 2 and its derivatives including 12a–16a (series A) and 11b–16b (series B). (a) tBuOK; (b) (i) LiBHEt3, THF; (ii) EDCI, DMF; (c). (i) CH3ONa, CH3OH, substituted benzaldehyde (ii) H2/Pd-C (only for 2, 12a–14a); (iii) MsCl, pyr (only for 11b14b); (d) PPTS, THF