Table 1.
Cytotoxicity of new derivatives of 21
| Compound | IC50 (μM)
|
|||
|---|---|---|---|---|
| A549 | MDA-MB-231 | KB | KB-VIN | |
| 2 | 5.50 ± 0.064 | 5.88 ± 0.10 | 9.90 ± 0.133 | 5.51 ± 0.16 |
| 12a | 5.72 ± 0.66 | 8.81 ± 0.46 | 6.47 ± 0.421 | 5.51 ± 0.29 |
| 15a | 6.17 ± 0.17 | > 40 | 11.5 ±1.94 | 6.78 ± 1.46 |
| 16a | 4.32 ± 0.093 | 8.55 ± 0.72 | 5.18 ± 0.160 | 4.84 ± 0.28 |
| 17a | 5.97 ±0.45 | 9.73 ± 0.084 | 9.20 ± 1.05 | 7.59 ± 0.44 |
| 18a | 4.80 ± 0.51 | 8.80 ± 0.16 | 5.40 ± 0.366 | 4.95 ± 0.35 |
| 19a | 5.93 ± 0.35 | 9.37 ± 0.29 | 8.71 ± 1.31 | 7.06 ± 0.39 |
| 20a | 3.32 ± 1.03 | 9.04 ± 1.32 | 4.98 ± 0.269 | 4.51 ± 0.50 |
| 21a | 6.15 ± 0.72 | 29.00 ± 2.87 | 18.10 ± 2.06 | 17.60 ± 1.06 |
| 22a | 5.02 ± 0.37 | 8.91 ± 0.44 | 5.53 ± 0.041 | 5.34 ± 0.37 |
| 11b | 35.17 ± 0.99 | > 40 | 34.0 ± 0.569 | 28.30 ± 2.04 |
| 12b | > 40 | > 40 | > 40 | > 40 |
| 15b | > 40 | > 40 | > 40 | > 40 |
| 16b | 31.24 ± 0.045 | > 40 | 34.0 ± 0.674 | 29.04 ± 2.07 |
| 17b | > 40 | > 40 | > 40 | > 40 |
| 18b | > 40 | > 40 | > 40 | > 40 |
| 19b | > 40 | > 40 | > 40 | > 40 |
| 20b | > 40 | > 40 | > 40 | > 40 |
| paclitaxel (nM) | 5.82 ± 0.19 | 5.34 ± 0.068 | 7.52 ± 0.020 | 1650 ± 55.70 |
1
Data are presented as the mean ± standard deviation (SD) determined in three separate experiments with duplicate assays