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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Cell Mol Bioeng. 2017 Oct 17;11(1):1–10. doi: 10.1007/s12195-017-0511-x

Figure 2. Knockdown of Girdin results in morphological differences.

Figure 2

(A) Time-lapse phase contrast images of a single control and Girdin siRNA-treated cell in a microtrack over a period of 120 minutes, yellow arrows and dashed outlines indicate the direction of migration and initial positions of cells at the beginning of migration, respectively; (B) Plotted aspect ratio of the same single control and Girdin siRNA-treated cells (showed in 3C) migrating through microtracks in a total time period of 120 minutes at 20 minutes intervals; (C) Average aspect ratio and (D) Average circularity of control and Girdin knockdown MDA-MB-231 cells in microtracks. Scale bars 25 µm, # of cells per treatment= 35, ** indicates p-value <0.01.