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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Hum Brain Mapp. 2017 Nov 3;39(2):644–661. doi: 10.1002/hbm.23870

Figure 3. Studying node versus subnodes in the default mode network.

Figure 3

Significant differences in functional connectivity (left column, resting-state functional connectivity [RSFC]) and structural co-occurrence (right column, voxel-based morphometry [VBM]). Schizophrenic patients and healthy controls were compared based on the usual DMN nodes (upper row) and the topographically more fine-grained DMN subnode atlas (lower row). Richer brain signals have been captured by the recent parcellation of the DMN nodes, resulting in a higher number of statistically significant group effects. Analysis approaches based on collapsed DMN nodes may therefore obfuscate disease-specific patterns in fMRI signals as indexed by resting-state connectivity and in MRI signals as indexed by voxel-based morphometry. The glass brains were created using the nilearn Python package (Abraham et al., 2014).