. Author manuscript; available in PMC: 2017 Nov 22.

Published in final edited form as: BMJ Paediatr Open. 2017 Nov 22;1:e000147. doi: 10.1136/bmjpo-2017-000147

Table 2.

Population pharmacokinetic parameter estimates

	Base model	Final model	Bootstrap (977/1000 successful)
Parameters	Population mean (%RSE)		Median (2.5 to 97.5 percentile)
Elimination rate (1/hour)	0.0317 (13%)	0.0408 (15%)	0.0411 (0.0318 to 0.0558)
Volume (L)	216 (22%)	233 (17%)	228 (167 to 312)
Absorption rate (1/hour)	3.43 (fixed)	3.43 (fixed)	3.43 (fixed)
Volume: age exponent	–	0.775 (13%)	0.780 (0.601 to 1.01)
Elimination rate: creatinine clearance exponent	–	0.850 (24%)	0.842 (0.470 to 1.25)
Fluconazole elimination rate (1/ hour)	–	0.0268 (5%)	0.0267 (0.0234 to 0.0321)
Between-subject variability
ω_ke²	0.219 (51%)	0.262 (40%)	0.256 (0.0858 to 0.590)
ω_V²	0.991 (27%)	0.329 (35%)	0.291 (0.0637 to 0.518)
Residual error	SD (%RSE)
Additive (μg/L)	4.24 (14%)	3.69 (13%)	3.65 (3.16 to 4.14)