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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: FEBS Lett. 2017 Nov 19;591(23):3850–3860. doi: 10.1002/1873-3468.12898

Fig. 2.

Fig. 2

Fitting extended beta distributions to measured amplitude histograms. (A) 4-state Markov model used for the generation of the theoretical amplitude histograms (extended beta distributions) by simulated current traces. (B,C) Representative current amplitude histograms of KcvNTS in 0.1 M KCl, pH 7 (gray) and the best fit with the model in (A) (black). Regions dominated by one of the closed states F, M or S are indicated. At +160 mV (B), both the closed (at 0 pA) and open peak (at 14.6 pA) are well defined. At -160 mV (C), the open peak is extremely broadened and skewed, corresponding to the large, asymmetric open-channel noise in the current trace (Fig. 1C).