Table 1.
Respiratory Viral Coinfections, Stratified by Age Group, in HIV-Uninfected Children Aged <5 Years With Respiratory Syncytial Virus–Associated Lower Respiratory Tract Infection at 6 Sentinel Sites in South Africa, 2009–2013
| All Ages (N = 2322) | <6 mo (n = 1287) | ≥6 mo (n = 1035) | |||||
|---|---|---|---|---|---|---|---|
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| Infection | Frequency | (%) | Frequency | (%) | Frequency | (%) | P Valuea |
| RSV monoinfection | 1330 | (57.3) | 824 | (64.0) | 506 | (48.9) | <.001 |
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| RSV + any coinfectionb | 992 | (42.7) | 463 | (36.0) | 529 | (51.1) | <.001 |
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| RSV-HMPV | 26 | (1.1) | 16 | (1.2) | 10 | (0.97) | .53 |
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| RSV-RV | 575 | (24.8) | 302 | (23.5) | 273 | (26.4) | .11 |
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| RSV-ADV | 347 | (14.9) | 107 | (8.3) | 240 | (23.2) | <.001 |
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| RSV-EV | 191 | (8.2) | 72 | (5.6) | 119 | (11.5) | <.001 |
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| RSV-Influenza | 30 | (1.3) | 11 | (0.85) | 19 | (1.8) | .04 |
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| RSV-PIV1 | 12 | (0.52) | 2 | (0.16) | 10 | (0.97) | .01 |
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| RSV-PIV2 | 12 | (0.52) | 4 | (0.31) | 8 | (0.77) | .12 |
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| RSV-PIV3 | 20 | (0.86) | 12 | (0.93) | 8 | (0.77) | .70 |
Abbreviations: ADV, adenovirus; EV, enterovirus; HIV, human immunodeficiency virus; HMPV, human metapneumovirus; PIV, parainfluenza virus; RSV, respiratory syncytial virus; RV, rhinovirus.
a
The P value is given for a comparison of the prevalence of a certain coinfection in the age group <6 mo and ≥6 mo.
b
Any viral respiratory coinfection with HMPV, RV, ADV, EV, influenza, PIV1, PIV2, or PIV3.