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. Author manuscript; available in PMC: 2018 Oct 3.
Published in final edited form as: JBMR Plus. 2017 Nov 21;2(1):32–47. doi: 10.1002/jbm4.10023

Table 1.

Transcription Factor Binding Motifs Identified by Genomatix MatIspector Analysis of Fgf23 −16kb Element

Detailed matrix information Strand Core similarity Matrix similarity Sequence
Hypoxia-response elements − 1 0.985 tcttggtaCGTGagtgt
Binding site of Clock/BMAL1 and NPAS2/BMAL1 heterodimers + 1 0.983 aagagtCACGtgtgctc
NF-κB (p65) − 1 0.974 ccaggactTTCCttt
STAT5 − 0.945 0.97 tagaTTCCtagaagtgaaa
STAT3 − 1 0.966 gctcTTCCagggaagtggt
AhR nuclear translocator homodimers − 1 0.963 tgagcacaCGTGactct
STAT6 + 1 0.951 ccacTTCCctggaagagct

Bioinformatic analysis of the −16kb region using the Genomatix software tool MatInspector reveals the presence of several transcription factor binding motifs associated with inflammatory signaling and corresponding sequences along with highest calculated matrix similarity scores (greater than 0.95).