Table 2.

Bone and Mineral Homeostasis in Fgf23^−16KO Mice

	Calcium (mg/dL)	Phosphate (mM)	PTH (pg/mL)
WT	10.7 ± 0.7	2.2 ± 0.5	55.2 ± 32.1
Fgf23−16KO	10.3 ± 0.8	2.3 ± 0.3	50.9 ± 17.8
	Bone Mineral Density (BMD)
	Femur	Spine	Global
WT	0.060 ± 0.005	0.045 ± 0.001	0.044 ± 0.002
Fgf23−16KO	0.058 ± 0.005	0.046 ± 0.002	0.043 ± 0.002

Analysis of serum calcium and phosphate and plasma PTH were performed on 8-week-old wild-type (WT) and Fgf23^−16KO male mice as explained in Materials and Methods. BMD of these mice were measured by DXA. The values represent mean ± SD of 6 to 8 mice/group. All statistical comparisons were performed using Student’s t test.

^*p < 0.05 compared with WT controls.