Table 3.

Summary of the Role of the −16kb Enhancer in Fgf23 Regulation in Response to Acute Inflammation and Kidney Disease

	Fgf23 mRNA levels								iFGF23 Plasma
	Bone	Bone marrow	Thymus	Spleen	Kidney	Intestine	Lung	Liver
IL-1β	+	+	+	+	+	+	+	+	+
Tnfα	+	+	+	+	+	+	+	−	+
LPS	+	+	+	+	−	+	+	+	+
Oxalate diet	+	UD	+	×	+	UD	UD	×	+

A comparison of the results of Fgf23 mRNA regulation by inflammatory cytokines and CKD in different tissues with levels in the circulation as observed in Figs. 3–7.

+ = −16kb enhancer plays a role in the Fgf23 induction; − = −16kb enhancer does not play a role in Fgf23 induction; X = Fgf23 is not regulated; UD = −Fgf23 levels were not measured.