Table 1.

Detection of oxidative DNA damage by o-quinones

Quinone	Treatment conditions	Lesion Type	Method of Detection	Reference
4-OHEN	4-OHEN + Sprague-Dawley rat mammary gland	DNA strand scission	Comet assay	Zhang et al.40
4-OHEN	4-OHEN + Sprague-Dawley rat mammary gland	8-Oxo-dG and 8-oxo-dA	SID-LC/MS/MS	Zhang et al.40
4-OHEN	4-OHEN + S30 human breast cancer cells	8-Oxo-dG	SID-LC/MS/MS and Comet assay coupled with Fpg	Wang et al.47
4-OHEN	4-OHEN + Calf thymus DNA + NADPH + CuCl2	8-Oxo-dG and apurinic sites/apyridiminic sites	SID-LC/MS/MS and aldehyde reactive probe	Wang et al.47
BPQ	BPQ + NADPH + CuCl2 + poly-dG:poly-dC or phage DNA	DNA strand scission	Electrophoresis	Flowers et al.45
BPQ	BPQ + NADPH + CuCl2 + calf thymus DNA	Apurinic sites/apyridiminic sites	Aldehyde reactive probe	Park et al.41
		8-Oxo-dG	EC-HPLC
BAQ	BAQ+ NADPH + CuCl2 + calf thymus DNA	Apurinic sites/apyridiminic sites	Aldehyde reactive probe	Park et al.41
		8-Oxo-dG	EC-HPLC	Seike et al.58
DMBAQ	DMBAQ + NADPH + CuCl2 + calf thymus DNA	Apurinic sites/apyridiminic sites	Aldehyde reactive probe	Park et al.41
		8-Oxo-dG	EC-HPLC
BPQ	BPQ + NADPH + CuCl2 + p53 plasmid DNA	8-Oxo-dG	EC-HPLC	Park et al.49
BAQ	BAQ + NADPH + CuCl2 + p53 plasmid DNA	8-Oxo-dG	EC-HPLC	Park et al.49
DMBAQ	DMBAQ + NADPH + CuCl2 + p53 plasmid DNA	8-Oxo-dG	EC-HPLC	Park et al.49
BPQ	BPQ + H358 human lung epithelial cells	8-Oxo-dG	SID-LC/MS/MS Comet assay coupled to OGG1	Mangal et al.82
BPQ	B[a]P-7,8-trans-dihydrodiol + A549 cells ± COMT inhibitor	8-Oxo-dG	SID-LC/MS/MS Comet assay coupled to OGG1	Park et al.96

4-OHEN = 4-hydroxyequilenin; BPQ = benzo[a]pyrene-7,8-dione; BAQ = benz[a]anthracene-3,4-dione; DMBAQ = 7,12-dimethylbenz[a]anthracene-3,4-dione.