Table 1. Biological processes and molecular function enrichment in HH genes closer than 500 bp.

Biological processes and molecular functions enriched in the genes that are oriented HH and closer than 1 Kb from each other. The number of genes observed with annotation for each process out of the 942 total genes in the group is shown, as well as the expected number based on the frequencies of annotations for all RefSeq genes. All values are calculated using the PANTHER bioinformatics engine and p values are Bonferroni corrected.

Biological Process	observed	expected	P value
DNA metabolism	39	13.14	6.0E-07
Nucleoside, nucleotide and nucleic acid metabolism	181	121.99	1.2E-06
DNA repair	24	6.17	6.9E-06
rRNA metabolism	12	2.41	1.2E-03
Other intracellular protein traffic	11	2.26	3.6E-03
Protein biosynthesis	40	21.57	2.9E-02
Chromatin packaging and remodeling	21	8.65	3.5E-02
Protein complex assembly	10	2.48	3.7E-02
Molecular Function	observed	expected	P value
Nucleic acid binding	170	104	3.51E-09
Histone	12	3.14	1.67E-02
Dehydrogenase	21	8.21	1.97E-02
Oxidoreductase	38	22	3.06E-02