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. Author manuscript; available in PMC: 2018 Mar 12.
Published in final edited form as: Genes Chromosomes Cancer. 2017 Dec 29;57(4):192–202. doi: 10.1002/gcc.22520

Table 2.

Significant microRNA (miRNA)-Transcription Factor(TF)-Target Gene (TG) interactions identified in normal colonic mucosa.

miRNA Mean Expression miRNA Beta
Co.		 TF Mean Expression TF Beta
Co.		 TG Mean Expression miRNA*TF
(interaction)
Beta Co.3 		miRNA-
TF Beta
Co.4 		P-Value
Tumor1 Normal Tumor1 Normal Tumor1 Normal Raw FDR
hsa-miR-1258 1.75 3.92 0.03 ZNF2632 95.39 44.41 0.68 CPM2 33.18 122.94 0.28 −0.23 <.0001 0.0177
hsa-miR-145-5p 134.57 207.91 0.18 CTCF 135.97 72.45 0.72 IGF1R2 365.93 187.47 0.15 0.21 0.0003 0.0228
hsa-miR-145-5p 134.57 207.91 0.18 ELF1 250.60 119.97 0.77 IGF1R2 365.93 187.47 0.15 0.21 <.0001 0.0177
hsa-miR-150-5p 15.27 40.22 −0.17 CTCF 135.97 72.45 0.75 VEGFA2 971.21 369.26 −0.20 0.24 0.0008 0.0354
hsa-miR-150-5p 15.27 40.22 −0.16 ELF1 250.60 119.97 0.81 VEGFA2 971.21 369.26 −0.23 0.22 <.0001 0.0177
hsa-miR-193b-3p 8.76 5.08 −0.12 CTCF 135.97 72.45 0.70 RRM22 172.47 37.43 −0.28 0.24 0.0003 0.0228
hsa-miR-193b-3p 8.76 5.08 −0.13 RBBP5 79.50 39.15 0.83 HELLS 268.00 82.11 −0.26 0.27 0.0002 0.0212
hsa-miR-193b-3p 8.76 5.08 −0.07 RBBP5 79.50 39.15 0.94 MAPK1IP1L2 270.04 167.11 −0.14 0.27 0.0002 0.0212
hsa-miR-193b-3p 8.76 5.08 −0.12 RBBP5 79.50 39.15 0.74 RAD512 20.32 9.74 −0.23 0.27 0.0007 0.0338
hsa-miR-193b-3p 8.76 5.08 −0.04 RBBP5 79.50 39.15 0.82 RCC1 137.97 46.22 −0.21 0.27 0.0006 0.0319
hsa-miR-193b-3p 8.76 5.08 −0.05 RBBP5 79.50 39.15 0.87 TJP2 412.82 182.83 −0.19 0.27 0.0004 0.0265
hsa-miR-330-3p 2.71 5.56 −0.08 ELF12 250.60 119.97 0.77 PTPLAD12 216.84 55.26 −0.19 −0.19 0.0005 0.0295
hsa-miR-4469 0.97 2.40 −0.09 ELF12 250.60 119.97 0.83 MRPS272 140.87 57.30 −0.14 −0.26 0.0009 0.0368

This table has been split into four groupings based on the directionality of the different beta coefficients. This has been done to assist in interpretation and following the discussion.

1

Tumor expression is shown for additional information only, and is not used in the calculation of any results in this table.

2

A seed match was identified between this TG and the miRNA.

3

This beta coefficient was generated from the two-way interaction analysis.

4

This beta coefficient was calculated in a separate linear regression between the miRNA and TF.