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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Virology. 2017 Dec 23;517:98–107. doi: 10.1016/j.virol.2017.12.006

Figure 2. Mouse-adapted M35c4 exhibits significant respiratory disease at low infectious doses.

Figure 2

Mice were infected intranasally with 5×103 (n = 13, black triangles), 5×104 (n = 12, blue squares), or 5×105 (n = 12, red circles) PFU of maM35c4. Mice were monitored daily for weight loss (a) and survival (b). The severity of hemorrhage was scored on a scale of 0 (no hemorrhage) to 4 (complete hemorrhage) (c), and lung titers were measured (d), for 288–330+/+ mice infected with the 5×103 dose at day 3 p.i. (n = 4) and day 7 p.i. (n = 9), 5×104 dose at day 3 p.i. (n = 4) and day 7 p.i. (n = 8), and 5×105 dose at day 3 p.i. (n = 4) and day 7 p.i. (n = 4). All data are represented as means ± S.E.M. For lung titers below the limit of detection values were set at 1 to depict those mice on the graph.