Table 1.

Lung histopathology from maM35c4-infected 288–330+/+ mice

		IHC Scoring		Airway Inflammation			Vasculatur e		Parenchym a (Alveoli)		Diffuse Alveolar Damage		Eosi noph ils
Vir al Do se	Har ves t Pos t Infe ctio n	Air wa y	Paren chym a	Denu datio n	De bri s	Inflam matio n	Periv ascul ar Cuffin g	Ed em a	Inter stiti al Sep tum	Airsp ace Inflam matio n	Hyali ne Mem bran e	Exu date s
5×105 PFU	Day 3 (n=4)	0.75 ± 0	2.69 ± 0.47	0.25 ± 0	0.69 ± 0.13	0.69 ± 0.13	0.94 ± 0.13	0.38 ± 0.14	0.81 ± 0.38	1.19 ± 0.24	0.00 ± 0	0.94 ± 0.52	0.31 ± 0.13
	Day 7 (n=4)	0.34 ± 0.19	0.84 ± 0.49	0.38 ± 0.14	0.69 ± 0.24	0.75 ± 0.35	1.31 ± 0.13	0.69 ± 0.24	0.75 ± 0.20	1.13 ± 0.48	1.56 ± 1.05	0.25 ± 0	0.50 ± 0
5×104 PFU	Day 3 (n=4)	0.50 ± 0	1.75 ± 0.54	0.31 ± 0.13	0.69 ± 0.59	0.50 ± 0.29	1.00 ± 0.35	0.31 ± 0.24	0.81 ± 0.38	0.75 ± 0.41	0.06 ± 0.13	0.75 ± 0.35	0.31 ± 0.13
	Day 7 (n=8)	0.11 ± 0.12	0.45 ± 0.44	0.25 ± 0	0.69 ± 0.26	0.88 ± 0.19	1.41 ± 0.40	0.53 ± 0.16	0.94 ± 0.18	1.50 ± 0.50	0.31 ± 0.51	0.41 ± 0.30	0.78 ± 0.28
5×103 PFU	Day 3 (n=4)	0.50 ± 0	1.75 ± 0.20	0.25 ± 0.20	0.56 ± 0.38	0.44 ± 0.24	0.69 ± 0.13	0.19 ± 0.24	0.63 ± 0.14	0.50 ± 0.29	0.00 ± 0	0.13 ± 0.14	0.44 ± 0.24
	Day 7 (n=9)	0.01 ± 0.04	0.13 ± 0.15	0.33 ± 0.18	0.69 ± 0.53	0.81 ± 0.27	1.44 ± 0.37	0.72 ± 0.23	1.33 ± 0.43	1.69 ± 0.41	0.00 ± 0	1.44 ± 0.72	0.50 ± 0
*Mock	Day 7 (n=3)	0.04 ± 0.07	0.08 ± 0.07	0.00 ± 0	0.00 ± 0	0.08 ± 0.14	0.21 ± 0.26	0.00 ± 0	0.25 ± 0.25	0.00 ± 0	0.00 ± 0	0.00 ± 0	0.00 ± 0

Disease scoring is based on a scale of 0–3 (0 = none and 3 = severe). Each value represents the mean ± standard deviation.

^*Mock mouse lungs were independently processed for purposes of histological comparison.