Pathogens detected in US children with CAP requiring hospitalization, detection according to age group. Darker shading in the bar graphin panel B indicates that only the single pathogen was detected, and lighter shading indicates the pathogen was detected in combination with at least one other pathogen. Panel A shows the proportion of pathogen types among 2222 hospitalized children in the CDC EPIC study. A total of 4 patients had more than one bacterial pathogen without a virus detected. Panel C shows the proportions of pathogens detected, according to age group. AdV, denotes adenovirus; CoV, coronavirus; Flu, influenza A or B virus; HMPV, human metapneumovirus; HRV, human rhinovirus; PIV, parainfluenza virus. (Data from Jain S, Williams DJ, Arnold SR, et al. Community-acquired pneumonia requiring hospitalization among U.S. children. NEJM 2015;372(9):840. Fig. 2; with permission.)