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. Author manuscript; available in PMC: 2009 Aug 4.
Published in final edited form as: J Neurosci. 2009 Feb 4;29(5):1469–1479. doi: 10.1523/JNEUROSCI.4240-08.2009

Figure 4.

Figure 4

NBQX reduces NMDAR EPSCs by blocking input from the rod pathway. A, CPPG-evoked EPSCs were reduced by NBQX (5 μM). B, the NBQX-sensitive component of the EPSC exhibited a J-shaped voltage dependence, indicating that it was mediated primarily by NMDARs. C, NBQX does not block NMDARs, as it did not affect responses in RGCs to exogenous NMDA (100 μM; Vhold = +40 mV). D, NBQX did not effect CPPG responses in RBCs, indicating that it did not act on mGluR6. E, NBQX blocked CPPG-evoked EPSCs in AII amacrine cells. F, NBQX strongly reduced CPPG responses in ON CBCs. G, As in F, but in a wild-type (WT) mouse ON CBC. H, NBQX did not affect CPPG responses in ON CBCs from Cx36 −/− mice. I, NBQX reduced CPPG-evoked EPSCs in RGCs from WT mice. J, NBQX also reduced CPPG-evoked EPSCs in Cx36 −/− mice, but to a lesser extent than in WT. K, Summarized effects of NBQX on CPPG-evoked responses in ON CBCs and RGCs. n values are indicated in parentheses.