Figure 4. An example of an epitope map of the novel avian H7N9 HA generated with escape mutant variants.

Vaccine-induced antibodies isolated from individuals vaccinated with a candidate H7N9 influenza A vaccine were used to generate escape mutant variants. Each residue indicated in red represents the location of critical amino acids required for efficient binding of a mAb. Data were adapted from Dunand-Henry et al., 2015⁴.