Table 3.

Total serum bilirubin among women and men stratified by UGT1A1 genotype and daily servings of foods assessed by 3DFR: interaction of genotype and diet¹

	Women				Men
Botanical family servings, n/d	6/6	6/7	7/7	P for interaction2	6/6	6/7	7/7	P for interaction2
	μmol/L				μmol/L
Total botanicals
<4	10.4 (8.9, 12.0) n=18	13.9 (12.2, 15.9) n=12	18.6 (14.2, 24.5) n=2	0.74	11.0 (9.2, 13.1) n=16	17.6 (15.4, 20.2) n=16	28.2 (21.5, 37.1) n=4	0.53
4–5	10.0 (9.2, 10.9) n=8	13.7 (12.7, 14.7) n=11	18.7 (16.0, 21.7) n=7		11.5 (10.4, 12.6) n=10	17.7 (16.3, 19.1) n=6	27.3 (23.3, 32.0) n=4
>5	9.6 (8.7, 10.7) n=39	13.4 (12.2, 14.7) n=30	18.7 (15.5, 22.5) n=6		11.9 (10.6, 13.4) n=39	17.7 (16.0, 19.7) n=27	26.4 (21.4, 32.5) n=7
Cruciferae
<0.5	9.8 (8.9, 10.8) n=50	13.4 (12.3, 14.4) n=41	18.2 (15.5, 21.3) n=12	0.78	11.3 (10.2, 12.5) n=52	17.4 (16.0, 19.0) n=37	26.9 (22.8, 31.9) n=13	0.45
0.5+	10.2 (8.5, 12.2) n=15	14.3 (12.3, 16.5) n=12	20.0 (14.9, 26.8) n=3		13.2 (10.7, 16.4) n=13	18.5 (15.4, 22.2) n=12	25.9 (17.9, 37.5) n=2
Rosaceae
<0.5	10.4 (9.2, 11.8) n=26	13.5 (12.2, 14.9) n=23	17.4 (14.3, 21.1) n=8	0.22	11.8 (10.3, 13.5) n=32	18.2 (16.2, 20.4) n=28	28.0 (22.3, 35.1) n=6	0.86
0.5+	9.5 (8.5, 10.6) n=39	13.8 (12.5, 15.2) n=30	19.9 (16.3, 24.2) n=7		11.4 (9.9, 13.0) n=33	17.2 (15.4, 19.3) n=21	26.1 (21.1, 32.2) n=9
Solanaceae
<0.5	10.0 (8.9, 11.3) n=30	13.7 (12.1, 15.4) n=17	18.6 (14.7, 23.7) n=5	0.94	10.7 (9.1, 12.6) n=21	18.1 (16.0, 20.5) n=19	30.6 (24.1, 38.9) n=6	0.11
0.5+	9.8 (8.8, 11.0) n=35	13.5 (12.4, 14.7) n=36	18.5 (15.6, 22.1) n=10		12.1 (10.8, 13.5) n=44	17.4 (15.7, 19.2) n=30	25.0 (20.5, 30.4) n=9
Leguminosae
<0.5	10.1 (8.8, 11.6) n=26	13.2 (11.6, 15.1) n=14	17.3 (13.3, 22.4) n=4	0.47	11.3 (9.8, 13.1) n=27	17.5 (15.5, 19.9) n=21	27.1 (21.2, 34.6) n=6	0.81
0.5+	9.8 (8.8, 10.9) n=39	13.7 (12.6, 14.8) n=39	19.1 (16.2, 22.5) n=11		11.8 (10.5, 13.3) n=38	17.8 (16.1, 19.8) n=28	26.9 (22.1, 32.8) n=9
Rutaceae
<0.5	9.3 (8.4, 10.3) n=39	13.7 (12.6, 14.8) n=39	20.0 (17.1, 23.5) n=11	0.03	11.2 (9.9, 12.7) n=37	17.7 (16.0, 19.6) n=29	28.1 (23.0, 34.2) n=9	0.37
0.5+	11.0 (9.6, 12.6) n=26	12.8 (11.2, 14.8) n=14	15.0 (11.4, 19.9) n=4		12.2 (10.6, 14.1) n=28	17.7 (15.6, 20.0) n=20	25.5 (20.0, 32.5) n=6
Umbelliferae
<0.5	10.0 (9.1, 10.9) n=55	13.8 (12.7, 14.9) n=39	19.0 (16.3, 22.1) n=14	0.77	11.9 (10.8, 13.2) n=56	17.4 (16.0, 19.0) n=41	25.4 (21.4, 30.2) n=11	0.08
0.5+	9.6 (7.8, 11.8) n=10	12.7 (10.7, 15.1) n=14	16.8 (11.7, 24.3) n=1		10.2 (8.0, 12.9) n=9	18.5 (15.5, 22.0) n=8	33.6 (24.5, 46.1) n=4

¹Bilirubin data were transformed ln(x+1). Back-transformed means and 95% CI (in parentheses) are presented.

²Adjusted for race, age, and total energy (total botanicals) or total botanicals (models for all other botanical families) using multiple linear regression