Table 2.

Identification of vascular calcification by statin eligibility. “Not statin eligible” was considered the referent category in logistic regression. Comparison of eligibility status was performed such that reclassification metrics and C-statistics represent the improvement of 2013 ACC/AHA guidelines over 2004 ATP-III guidelines. Detailed methods described in text. Abbreviations: AAC, abdominal aortic calcium score; CAC, coronary artery calcium score; NRI, net reclassification index; Ref, referent category.

Eligibility	CAC score >0 (N=756/1790 participants)			CAC score ≥100 (N=327/1790 participants)			AAC score >0 (N=1145/1789 participants)
	Number with CAC (%)	Statistic (95% CI)	p value	Number with CAC≥100 (%)	Statistic (95% CI)	p value	Number with AAC (%)	Statistic (95% CI)	p value
2013 ACC/AHA guidelines
Statin eligible	526/844 (62.3)	5.1 (4.2–6.3)	<0.0001	261/844 (30.9)	6.0 (4.5–8.0)	<0.0001	707/843 (83.9)	6.0 (4.8–7.5)	<0.0001
Not statin eligible	230/946 (24.3)	1 (Ref)		66/946 (7.0)	1 (Ref)		438/946 (46.3)	1 (Ref)
C-statistic	0.69 (0.67–0.72)			0.70 (0.67–0.73)			0.70 (0.68–0.72)
2004 ATP-III guidelines
Statin eligible	301/470 (64.0)	3.4 (2.7–4.2)	<0.0001	160/470 (34.0)	3.6 (2.8–4.6)	<0.0001	396/469 (84.4)	4.1 (3.1–5.4)	<0.0001
Not statin eligible	455/1320 (34.5)	1 (Ref)		167/1320 (12.7)	1 (Ref)		749/1320 (56.7)	1 (Ref)
C-statistic	0.62 (0.60–0.64)			0.64 (0.61–0.67)			0.62 (0.60–0.63)
Statin eligibility comparison (2013 ACC/AHA vs. 2004 ATP-III)
ΔC-statistic	0.08 (0.06–0.10)		<0.0001	0.06 (0.03–0.09)		<0.0001	0.09 (0.07–0.11)		<0.0001
NRI	0.15 (0.11–0.20)		<0.0001	0.12 (0.06–0.18)		0.0006	0.17 (0.14–0.21)		<0.0001
Individuals with CAC correctly reclassified by ACC/AHA	30%		<0.0001	31%		<0.0001	27%		<0.0001
Individuals without CAC incorrectly reclassified by ACC/AHA	−14%		<0.0001	−19%		<0.0001	−10%		<0.0001