Table 1.

Demographics, SULF1, and SULF2 measurements by cognitive status

	Normal Cognition n = 20	Alzheimer’s Disease n = 20	p-value
Age, y mean (SD)	86.4 (6.4)	86.9 (6.3)
Sex, % women	65%	65%
SULF2*
Hippocampus
CA	8.33 (1.28)	6.44 (2.04)	0.003
Gray matter	7.60 (1.96)	5.55 (2.09)	0.003
White matter	1.10 (0.31)	1.10 (0.45)	0.99
Frontal
Gray matter	7.35 (1.53)	5.40 (2.11)	0.002
White matter	1.20 (0.41)	1.35 (1.31)	0.63
SULF1*
Hippocampus
CA	0.00 (0.00)	0.00 (0.00)	0.99
Gray matter	1.35 (1.35)	1.40 (1.31)	0.91
White matter	2.00 (1.75)	1.50 (1.36)	0.32
Frontal
Gray matter	1.20 (1.51)	1.30 (1.12)	0.81
White matter	1.15 (1.35)	1.45 (1.43)	0.50
Braak staging, n (%)
I	8 (40.0)	0 (0.0)
II	7 (35.0)	0 (0.0)
III	5 (25.0)	0 (0.0)
IV	0 (0.0)	0 (0.0)
V	0 (0.0)	4 (20.0)
VI	0 (0.0)	16 (80.0)

^*Composite immunohistochemistry score: proportion of cells stained by intensity of staining.