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. Author manuscript; available in PMC: 2018 Aug 13.
Published in final edited form as: Oncogene. 2018 May 2;37(32):4385–4397. doi: 10.1038/s41388-018-0278-0

Figure 7. A Schematic depiction of the mechanism of CD105/BMP signaling in conferring radiation resistance.

Figure 7

Radiation of prostate cancer results in upregulation of cell surface CD105 expression. The ensuing CD105/BMP signaling is essential and necessary for SIRT1 expression and downstream activity. SIRT1 facilitates DNA damage repair, destabilizes p53, and activates of PGC-1α in response to radiation. Consequently, CD105 can regulate glycolysis and mitochondrial biogenesis to meet the higher energy demands necessary for survival following irradiation. The loss of functional p53 enables glycolysis as a source of ATP generation and survival.