Table 2. The input information and the output meta-analysis results of 7 Caucasian cohorts based on GWAMA (default setting).
Cohorts | MARKER | EA | NEA | OR | OR_95L | OR_95U | N (cases+controls) | P |
---|---|---|---|---|---|---|---|---|
GoDARTS (severe DR, type 2) | rs3913535 | C | T | 1.55 | 1.34 | 1.79 | 4666(560+4,106) | 4.05×10-9 |
rs10765219 | T | G | 1.54 | 1.31 | 1.80 | 4666 | 7.41×10-8 | |
rs11018670 | G | A | 1.55 | 1.33 | 1.80 | 4666 | 1.23×10-8 | |
| ||||||||
SDR (general DR, type 2) | rs3913535 | C | T | 0.98 | 0.95 | 1.01 | 2016 (1,151+865) | 0.25 |
rs10765219 | T | G | 1.04 | 1.004 | 1.07 | 2016 | 0.02 | |
rs11018670 | G | A | 1.03 | 1.004 | 1.07 | 2016 | 0.03 | |
| ||||||||
AUST (general DR, type2) | rs3913535 | C | T | 1.05 | 0.84 | 1.30 | 780(346+434) | 0.68 |
rs10765219 | T | G | 1.04 | 0.84 | 1.28 | 780 | 0.73 | |
rs11018670 | G | A | 1.05 | 0.85 | 1.30 | 780 | 0.62 | |
| ||||||||
BMES (general DR, type2) | rs3913535 | C | T | 1.89 | 0.90 | 3.99 | 162 (15+147) | 0.09 |
rs10765219 | T | G | 2.76 | 1.31 | 5.79 | 162 | 0.007 | |
rs11018670 | G | A | 2.85 | 1.35 | 6.02 | 162 | 0.006 | |
| ||||||||
CHS2 (general DR, type 2) | rs3913535 | C | T | 1.12 | 0.30 | 4.11 | 116 (5+111) | 0.87 |
rs10765219 | T | G | 1.67 | 0.47 | 5.92 | 116 | 0.43 | |
rs11018670 | G | A | 1.69 | 0.48 | 5.93 | 116 | 0.42 | |
| ||||||||
FinnDiane (general DR, Type 1) | rs3913535 | C | T | 1.05 | 0.92 | 1.21 | 2670 (1,638+1,032) | 0.53 |
rs10765219 | T | G | 1.13 | 0.99 | 1.29 | 2670 | 0.08 | |
rs11018670 | G | A | 1.09 | 0.95 | 1.23 | 2670 | 0.23 | |
| ||||||||
GoKinD;EDIC (general DR type1) | rs3913535 | C | T | 1.03 | 0.91 | 1.16 | 2829 (973+1,856) | 0.52 |
rs10765219 | T | G | 1.08 | 0.95 | 1.22 | 2829 | 0.21 | |
rs11018670 | G | A | 1.05 | 0.91 | 1.21 | 2829 | 0.42 | |
| ||||||||
Meta-analysis without GoDARTS | rs3913535 | C | T | 0.99 | 0.96 | 1.02 | 8573 (4,128+4,445) | 0.42 |
rs10765219 | T | G | 1.05 | 1.02 | 1.08 | 8573 | 0.003 | |
rs11018670 | G | A | 1.03 | 1.01 | 1.06 | 8573 | 0.007 | |
| ||||||||
Meta-analysis all Caucasian cohorts | rs3913535 | C | T | 1.01 | 0.98 | 1.03 | 13239 (4688+8,551) | 0.71 |
rs10765219 | T | G | 1.07 | 1.03 | 1.10 | 13239 | 9.02×10-5 | |
rs11018670 | G | A | 1.04 | 1.02 | 1.07 | 13239 | 4.24×10-4 |
EA: effective allele
NEA: non-effective allele
OR: odds ratio
N: number
GoDARTS: The Genetics of Diabetes Audit and Research Tayside
SDR: The Scania Diabetes Registry
AUST: The Australian DR Genetics Case-Control Study
BMES: The Blue Mountain Eye Study
CHS2: Cardiovascular Health Study 2
FinnDiane: The Finnish Diabetic Nephropathy Study
GoKinD: The Genetics of Kidneys in Diabetes study
EDIC: The Epidemiology of Diabetes Interventions and Complications