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. Author manuscript; available in PMC: 2018 Dec 11.
Published in final edited form as: Acta Ophthalmol. 2018 Sep 4;96(7):e811–e819. doi: 10.1111/aos.13769

Table 2. The input information and the output meta-analysis results of 7 Caucasian cohorts based on GWAMA (default setting).

Cohorts MARKER EA NEA OR OR_95L OR_95U N (cases+controls) P
GoDARTS (severe DR, type 2) rs3913535 C T 1.55 1.34 1.79 4666(560+4,106) 4.05×10-9
rs10765219 T G 1.54 1.31 1.80 4666 7.41×10-8
rs11018670 G A 1.55 1.33 1.80 4666 1.23×10-8

SDR (general DR, type 2) rs3913535 C T 0.98 0.95 1.01 2016 (1,151+865) 0.25
rs10765219 T G 1.04 1.004 1.07 2016 0.02
rs11018670 G A 1.03 1.004 1.07 2016 0.03

AUST (general DR, type2) rs3913535 C T 1.05 0.84 1.30 780(346+434) 0.68
rs10765219 T G 1.04 0.84 1.28 780 0.73
rs11018670 G A 1.05 0.85 1.30 780 0.62

BMES (general DR, type2) rs3913535 C T 1.89 0.90 3.99 162 (15+147) 0.09
rs10765219 T G 2.76 1.31 5.79 162 0.007
rs11018670 G A 2.85 1.35 6.02 162 0.006

CHS2 (general DR, type 2) rs3913535 C T 1.12 0.30 4.11 116 (5+111) 0.87
rs10765219 T G 1.67 0.47 5.92 116 0.43
rs11018670 G A 1.69 0.48 5.93 116 0.42

FinnDiane (general DR, Type 1) rs3913535 C T 1.05 0.92 1.21 2670 (1,638+1,032) 0.53
rs10765219 T G 1.13 0.99 1.29 2670 0.08
rs11018670 G A 1.09 0.95 1.23 2670 0.23

GoKinD;EDIC (general DR type1) rs3913535 C T 1.03 0.91 1.16 2829 (973+1,856) 0.52
rs10765219 T G 1.08 0.95 1.22 2829 0.21
rs11018670 G A 1.05 0.91 1.21 2829 0.42

Meta-analysis without GoDARTS rs3913535 C T 0.99 0.96 1.02 8573 (4,128+4,445) 0.42
rs10765219 T G 1.05 1.02 1.08 8573 0.003
rs11018670 G A 1.03 1.01 1.06 8573 0.007

Meta-analysis all Caucasian cohorts rs3913535 C T 1.01 0.98 1.03 13239 (4688+8,551) 0.71
rs10765219 T G 1.07 1.03 1.10 13239 9.02×10-5
rs11018670 G A 1.04 1.02 1.07 13239 4.24×10-4

EA: effective allele

NEA: non-effective allele

OR: odds ratio

N: number

GoDARTS: The Genetics of Diabetes Audit and Research Tayside

SDR: The Scania Diabetes Registry

AUST: The Australian DR Genetics Case-Control Study

BMES: The Blue Mountain Eye Study

CHS2: Cardiovascular Health Study 2

FinnDiane: The Finnish Diabetic Nephropathy Study

GoKinD: The Genetics of Kidneys in Diabetes study

EDIC: The Epidemiology of Diabetes Interventions and Complications