Table 3.
ORs (95% CIs) of In-Hospital Mortality Following TBI Comparing Statin Users and Nonusers by Individual Months Prior to TBI.
| Unadjusted
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|---|---|---|---|---|---|---|
| Use in Months Prior to TBI
|
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| −1 | −2 | −3 | −4 | −5 | −6 | |
| Any statin use | 0.96 (0.92, 1.00) | 0.94 (0.82, 1.08) | 1.07 (0.90, 1.26) | 1.15 (0.95, 1.39) | 0.92 (0.72, 1.16) | 0.95 (0.73, 1.22) |
| Atorvastatin | 1.00 (0.94, 1.07) | 0.89 (0.71, 1.11) | 1.12 (0.71, 1.11) | 1.26 (0.97, 1.62) | 0.99 (0.74, 1.34) | 0.64 (0.44, 0.93) |
| Fluvastatin | 0.74 (0.50, 1.09) | 0.39 (0.05, 2.84) | 0.69 (1.17, 2.91) | 0.69 (0.17, 2.91) | 0.50 (0.07, 3.69) | NAa |
| Lovastatin | 1.03 (0.91, 1.16) | 0.89 (0.55, 1.44) | 1.81 (1.15, 2.84) | 0.92 (0.48, 1.75) | 1.40 (0.82, 2.40) | 1.31 (0.72, 2.38) |
| Pravastatin | 1.04 (0.92, 1.18) | 0.87 (0.53, 1.43) | 0.73 (0.37, 1.43) | 1.03 (0.54, 1.98) | 0.63 (0.28, 1.43) | 1.22 (0.61, 2.43) |
| Rosuvastatin | 0.83 (0.71, 0.97) | 1.44 (0.98, 2.10) | 0.46 (0.21, 0.98) | 0.79 (0.40, 1.56) | 1.21 (0.68, 2.14) | 0.51 (0.21, 1.26) |
| Simvastatin | 0.93 (0.88, 0.99) | 0.93 (0.77, 1.14) | 1.00 (0.78, 1.27) | 1.08 (0.82, 1.42) | 0.71 (0.50, 1.01) | 1.11 (0.81, 1.51) |
|
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| Adjustedb | ||||||
|
|
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| Use in Months Prior to TBI | ||||||
|
|
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| −1 | −2 | −3 | −4 | −5 | −6 | |
|
| ||||||
| Any statin use | 0.89 (0.84, 0.94) | 0.84 (0.71, 0.98) | 0.98 (0.81, 1.18) | 0.98 (0.79, 1.23) | 0.86 (0.66, 1.12) | 0.81 (0.61, 1.08) |
| Atorvastatin | 0.91 (0.84, 0.99) | 0.74 (0.57, 0.96) | 0.18 (0.90, 1.53) | 1.12 (0.83, 1.50) | 0.98 (0.70, 1.36) | 0.60 (0.40, 0.91) |
| Fluvastatin | 0.74 (0.47, 1.15) | 0.63 (0.08, 4.67) | 0.95 (0.22, 4.04) | 1.06 (0.25, 4.52) | 0.58 (0.08, 4.40) | N/Aa |
| Lovastatin | 1.01 (0.87, 1.16) | 0.72 (0.40, 1.28) | 1.17 (0.65, 2.09) | 1.01 (0.49, 2.09) | 1.43 (0.80, 2.56) | 1.03 (0.50, 2.14) |
| Pravastatin | 0.97 (0.84, 1.12) | 0.83 (0.48, 1.44) | 0.79 (0.39, 1.62) | 0.73 (0.32, 1.67) | 0.36 (0.12, 1.07) | 1.00 (0.43, 2.34) |
| Rosuvastatin | 0.74 (0.62, 0.89) | 1.54 (1.00, 2.37) | 0.54 (0.24, 1.23) | 0.88 (0.42, 1.85) | 1.10 (0.55, 2.21) | 0.68 (0.27, 1.71) |
| Simvastatin | 0.86 (0.80, 0.92) | 0.86 (0.69, 1.08) | 0.89 (0.68, 1.18) | 0.91 (0.66, 1.25) | 0.68 (0.46, 1.02) | 0.94 (0.65, 1.34) |
Abbreviations: OR, odds ratio; CI, confidence interval; TBI, traumatic brain injury; CHF, congestive heart failure; AMI, acute myocardial infarction; IHD, ischemic heart disease; VHD, valvular heart disease; ADRD, Alzheimer’s disease and related dementias; SNF, skilled nursing facility; SRRi, independent survival risk ratio.
Estimate too small and unreliable.
Adjusted for demographic characteristics (age, sex, race, income, region); medications (antiplatelets, anticoagulants, beta-blockers, other statins); cardiovascular disease (CHF, AMI, IHD, VHD, hyperlipidemia, hypertension, prior stroke); diabetes; Alzheimer’s disease and related dementia; count of CCW chronic conditions excluding cardiovascular conditions (hypertension, hyperlipidemia, ischemic heart disease, congestive heart failure, acute myocardial infarction, valvular heard disease) and diabetes and ADRD; SNF stay in month prior to TBI; injury severity (SRRi, length of hospital stay); provider and hospital characteristics per 100 000 population (physicians, hospitals, hospitals with trauma services, hospitals with neurological services, beds).