. Author manuscript; available in PMC: 2018 Oct 12.

Published in final edited form as: J Pharm Technol. 2017 Oct 12;33(6):225–236. doi: 10.1177/8755122517735656

Appendix Table 4.

ORs (95% CIs) of In-Hospital Mortality Following TBI Comparing Statin Users and Nonusers Among Beneficiaries That Died Within 24 Hours of Hospitalization (n = 110 970).

	Unadjusted
	Current Use	Recent Use	Past Use
Any statin use	0.95 (0.91, 1.00)	1.08 (0.95, 1.24)	0.92 (0.76, 1.10)
Atorvastatin	0.99 (0.92, 1.06)	1.16 (0.96, 1.40)	0.77 (0.60, 0.99)
Fluvastatin	0.69 (0.46, 1.04)	0.79 (0.29, 2.16)	0.36 (0.05, 2.61)
Lovastatin	1.00 (0.88, 1.14)	1.37 (0.93, 2.03)	1.37 (0.89, 2.08)
Pravastatin	1.04 (0.92, 1.19)	0.82 (0.50, 1.36)	0.80 (0.45, 1.44)
Rosuvastatin	0.86 (0.73, 1.00)	0.55 (0.32, 0.96)	0.88 (0.53, 1.47)
Simvastatin	0.93 (0.88, 0.99)	1.04 (0.85, 1.24)	0.91 (0.71, 1.16)

	Adjusted^a

	Current Use	Recent Use	Past Use

Any statin use	0.87 (0.82, 0.92)	0.98 (0.84, 1.15)	0.82 (0.67, 1.01)
Atorvastatin	0.88 (0.81, 0.95)	0.13 (0.92, 1.40)	0.73 (0.55, 0.97)
Fluvastatin	0.67 (0.42, 1.07)	1.10 (0.39, 3.06)	0.42 (0.06, 3.14)
Lovastatin	0.96 (0.83, 1.11)	1.07 (0.67, 1.72)	1.26 (0.79, 2.02)
Pravastatin	0.94 (0.82, 1.09)	0.75 (0.42, 1.33)	0.50 (0.24, 1.07)
Rosuvastatin	0.76 (0.64, 0.91)	0.62 (0.34, 1.14)	0.88 (0.49, 1.57)
Simvastatin	0.85 (0.79, 0.91)	0.90 (0.72, 1.12)	0.81 (0.62, 1.07)

Abbreviations: OR, odds ratio; CI, confidence interval; TBI, traumatic brain injury; CHF, congestive heart failure; AMI, acute myocardial infarction; IHD, ischemic heart disease; VHD, valvular heart disease; ADRD, Alzheimer’s disease and related dementias; SNF, skilled nursing facility; SRRi, independent survival risk ratio.

Adjusted for demographic characteristics (age, sex, race, income, region); medications (antiplatelets, anticoagulants, beta blockers, other statins); cardiovascular disease (CHF, AMI, IHD, VHD, hyperlipidemia, hypertension, prior stroke); diabetes; Alzheimer’s disease and related dementia; count of CCW chronic conditions excluding cardiovascular conditions (hypertension, hyperlipidemia, ischemic heart disease, congestive heart failure, acute myocardial infarction, valvular heard disease) and diabetes and ADRD; SNF stay in month prior to TBI; injury severity (SRRi, length of hospital stay); provider and hospital characteristics per 100 000 population (physicians, hospitals, hospitals with trauma services, hospitals with neurological services, beds).