Appendix Table 5.
ORs (95% CIs) of In-Hospital Mortality Following TBI Comparing Statin Users and Nonusers, by Individual Months Prior to TBI Among Beneficiaries Who Did Not Die Within 24 Hours of Hospitalization (n = 110 970).
| Unadjusted
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|---|---|---|---|---|---|---|---|
| Use in Months Prior to TBI
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| −1 | −2 | −3 | −4 | −5 | −6 | ||
| Any statin use | 0.95 (0.91, 1.00) | 0.93 (0.80, 1.08) | 1.05 (0.88, 1.25) | 1.13 (0.88, 1.25) | 0.92 (0.72, 1.18) | 0.91 (0.69, 1.19) | |
| Atorvastatin | 1.00 (0.93, 1.08) | 0.82 (0.64, 1.05) | 1.12 (0.87, 1.45) | 1.20 (0.91, 1.59) | 0.98 (0.72, 1.35) | 0.55 (0.36, 0.84) | |
| Fluvastatin | 0.71 (0.47, 1.08) | 0.44 (0.06, 3.21) | 0.79 (0.19, 3.29) | 0.79 (1.19, 3.29) | 0.56 (0.08, 4.17) | N/Aa | |
| Lovastatin | 1.01 (0.88, 1.15) | 0.95 (0.58, 1.56) | 1.68 (1.02, 2.75) | 1.04 (0.54, 1.98) | 1.37 (0.77, 2.44) | 1.35 (0.73, 2.53) | |
| Pravastatin | 1.05 (0.92, 1.20) | 0.98 (0.60, 1.61) | 0.73 (0.36, 1.50) | 0.94 (0.46, 1.92) | 0.47 (0.17, 1.28) | 1.23 (0.59, 2.54) | |
| Rosuvastatin | 0.82 (0.69, 0.96) | 1.24 (0.81, 1.91) | 0.44 (0.20, 1.00) | 0.70 (0.33, 1.49) | 1.26 (0.69, 2.28) | 0.47 (0.17, 1.26) | |
| Simvastatin | 0.93 (0.87, 0.99) | 0.96 (0.78, 1.18) | 0.97 (0.75, 1.26) | 1.10 (0.82, 1.46) | 0.73 (0.51, 1.06) | 1.11 (0.80, 1.54) | |
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| Adjustedb | |||||||
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| Use in Months Prior to TBI | |||||||
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| −1 | −2 | −3 | −4 | −5 | −6 | ||
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| Any statin use | 0.89 (0.84, 0.94) | 0.84 (0.71, 0.99) | 0.97 (0.79, 1.18) | 1.01 (0.80, 1.28) | 0.87 (0.66, 1.14) | 0.78 (0.57, 1.06) | |
| Atorvastatin | 0.91 (0.84, 0.99) | 0.71 (0.54, 0.93) | 1.16 (0.88, 1.53) | 1.12 (0.82, 1.53) | 0.94 (0.66, 1.33) | 0.53 (0.33, 0.84) | |
| Fluvastatin | 0.68 (0.42, 1.10) | 0.69 (0.09, 5.11) | 1.02 (0.24, 4.34) | 1.16 (0.27, 4.93) | 0.64 (0.09, 4.89) | N/Aa | |
| Lovastatin | 0.98 (0.85, 1.14) | 0.79 (0.44, 1.41) | 1.05 (0.57, 1.96) | 1.11 (0.54, 2.30) | 1.44 (0.78, 2.64) | 1.08 (0.51, 2.26) | |
| Pravastatin | 0.97 (0.83, 1.12) | 0.90 0.52, 1.55) | 0.77 (0.36, 1.64) | 0.73 (0.31, 1.73) | 0.21 (0.05, 0.84) | 0.94 (0.38, 2.30) | |
| Rosuvastatin | 0.72 (0.60, 0.87) | 1.30 (0.81, 2.09) | 0.49 (0.20, 1.20) | 0.81 (0.36, 1.83) | 1.08 (0.53, 2.23) | 0.65 (0.24, 1.79) | |
| Simvastatin | 0.86 (0.80, 0.93) | 0.89 (0.71, 1.11) | 0.88 (0.66, 1.18) | 0.93 (0.67, 1.30) | 0.71 (0.47, 1.07) | 0.94 (0.64, 1.36) | |
Abbreviations: OR, odds ratio; CI, confidence interval; TBI, traumatic brain injury; CHF, congestive heart failure; AMI, acute myocardial infarction; IHD, ischemic heart disease; VHD, valvular heart disease; ADRD, Alzheimer’s disease and related dementias; SNF, skilled nursing facility; SRRi, independent survival risk ratio.
Estimate too small and unreliable.
Adjusted for demographic characteristics (age, sex, race, income, region); medications (antiplatelets, anticoagulants, beta-blockers, other statins); cardiovascular disease (CHF, AMI, IHD, VHD, hyperlipidemia, hypertension, prior stroke); diabetes; Alzheimer’s disease and related dementia; count of CCW chronic conditions excluding cardiovascular conditions (hypertension, hyperlipidemia, ischemic heart disease, congestive heart failure, acute myocardial infarction, valvular heard disease) and diabetes and ADRD; SNF stay in month prior to TBI; injury severity (SRRi, length of hospital stay); provider and hospital characteristics per 100 000 population (physicians, hospitals, hospitals with trauma services, hospitals with neurological services, beds).