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The four molecular subtypes of endometrial carcinoma
| Mutation profile | Surrogate marker (genetic) | Surrogate marker (IHC) |
|---|---|---|
| Ultramutated | POLE mutation | none available |
| Hypermutated | MSI-H | MMR-D |
| Copy-number high | TP53 mutation | p53 abn |
| Copy-number low | absence of other markers | absence of other markers (p53 wt) |
MSI-H, microsatellite instability (high); MMR-D, mismatch repair deficient; abn, abnormal; wt, wild type
