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. Author manuscript; available in PMC: 2009 Aug 12.
Published in final edited form as: J Neurosci. 2008 Jun 18;28(25):6407–6418. doi: 10.1523/JNEUROSCI.1425-08.2008

Table 1. Responsiveness to tested synthetic compounds.

The denominator in the responsive electrodes column indicates the number of recording sites on which the given ligand was tested; it includes only active electrodes that responded to at least one stimulus, including hundred-fold diluted urine and high potassium. The numerator indicates the number of these electrodes that responded to the specific ligand. Compounds in the first part of the table, labeled with a single letter follwed by 4 digits, are sulfated steroids, except for the glucuronidated steroid Q3470 (Fig. S2). Nomenclature is from the Steraloids catalog.

Compounds were tested at a concentration of 100 μM except where indicated. References: AAPDNRETF, SYFPEITHI (Leinders-Zufall et al., 2004).

EEARSM (Mucignat-Caretta et al., 1995).

ESP1 (Kimoto et al., 2005)., rMUP1 (Chamero et al., 2007) (*Note: responses reported by Chamero et al. occurred at concentrations higher than 0.1 μM.)

Acetic acid, butyric acid, propionic acid, isobutyric acid, isovaleric acid (Michael et al., 1971).

Pentyl acetate (Novotny et al., 1986; Leinders-Zufall et al., 2000; Punta et al., 2002).

2-heptanone (Jemiolo et al., 1989; Novotny et al., 1986; Leinders-Zufall et al., 2000; Boschat et al., 2002; Punta et al., 2002; Sam et al., 2001; Trinh & Storm, 2003). Isobutylamine (Punta et al., 2002).

2,5-dimethylpyrazine (Novotny et al., 1986; Leinders-Zufall et al., 2000; Punta et al., 2002; Sam et al., 2001; Trinh & Storm, 2003),

α and β farnesenes (Ma et al., 1999; Novotny et al., 1990, 1999; Leinders-Zufall et al., 2000; Sam et al., 2001; Punta et al., 2002).

Dimethyl disulfide (Singer et al., 1976).

Arginine, methionine, glutamate, indole, muscone, patchone, p-cresol, eucalyptol, fenchone, borneol, isoborneol, aubepine, butyrophenone, phenafleur (Sam et al., 2001).

Ethyl acetate, ethyl propionate, ethyl vanilline, butanone (Trinh & Storm, 2003).

Stimulus Female Male trpc2-/- Female,% Male,% trpc2,%
A0225 6/42 1/64 0/21 14.3 1.6 0
A2398 1/42 5/64 0/21 2.4 7.8 0
A2460 4/42 2/64 0/21 9.5 3.1 0
A2534 (50 μM) 1/42 2/64 0/21 2.4 3.1 0
A6940 (100 and 50 μM) 6/42 5/182 0/21 14.3 2.7 0
A7010 (100 and 50 μM) 5/42 7/182 0/21 11.9 3.8 0
A7864 2/42 8/64 0/21 4.8 12.5 0
A8530 0/42 2/64 0/21 0 3.1 0
C4385 0/42 0/64 0/21 0 0 0
C5075 (10 μM) 0/42 0/64 0/21 0 0 0
C6905 (50 μM) 0/42 1/64 0/21 0 1.6 0
E0588 3/42 1/64 0/21 7.1 1.6 0
E0893 0/42 2/64 0/21 0.0 3.1 0
E1050 2/42 4/64 0/21 4.8 6.3 0
E1100 1/42 0/64 0/21 2.4 0 0
E1103 1/42 1/64 0/21 2.4 1.6 0
E2335 0/42 0/64 0/21 0 0 0
E2732 0/42 0/64 0/21 0 0 0
E4105 (50 μM) 3/42 5/182 0/21 7.1 2.7 0
P2135 (50 μM) 2/42 7/182 0/21 4.8 3.8 0
P3817 9/42 11/64 0/21 21.4 17.2 0
P3865 (100 and 50 μM) 1/42 4/182 0/21 2.4 2.2 0
P8168 4/42 2/64 0/21 9.5 3.1 0
P8200 8/42 11/64 0/21 19.0 17.2 0
Q1570 (cort21S) (100 and 50 μM) 1/42 16/183 0/21 2.4 8.7 0
Q1890 0/42 2/64 0/21 0 3.1 0
Q2525 2/42 2/64 0/21 4.8 3.1 0
Q3383 (100 and 50 μM) 1/42 0/182 0/21 2.4 0 0
Q3470 (50 μM) n.t. 7/118 n.t. n.t. 5.9 n.t.
Q3910 3/42 6/64 0/21 7.1 9.4 0
Q4765 (50 μM) 0/42 1/64 0/21 0 1.6 0
Q5545 1/42 8/64 0/21 2.4 12.5 0
ESP1 (0.1 μM) 3/166 0/93 n.t. 1.8 0 n.t.
rMUP1 (0.1 μM)* 0/166 0/93 n.t. 0 0 n.t.
AAPDNRETF (1 and 0.1 μM) 0/35 0/104 n.t. 0 0 n.t.
SYFPEITHI (1 and 0.1 μM) 0/35 0/104 n.t. 0 0 n.t.
EEARSM (0.1 μM) n.t. 0/93 n.t. n.t. 0 n.t.
acetic acid 0/35 n.t. n.t. 0 n.t. n.t.
arginine 0/35 0/93 n.t. 0 0 n.t.
aubepine 0/69 1/117 n.t. 0 0.9 n.t.
borneol 0/69 0/117 n.t. 0 0 n.t.
butanone 0/69 0/117 n.t. 0 0 n.t.
butyric acid n.t. 2/93 n.t. n.t. 2.2 n.t.
butyrophenone 0/69 0/117 n.t. 0 0 n.t.
p-cresol 0/69 0/117 n.t. 0 0 n.t.
dimethyl disulfide n.t. 0/117 n.t. n.t. 0 n.t.
2,5-dimethylpyrazine 0/69 0/130 n.t. 0 0 n.t.
ethyl acetate 0/69 0/117 n.t. 0 0 n.t.
ethyl propionate 0/69 0/117 n.t. 0 0 n.t.
ethyl vanilline 0/69 0/117 n.t. 0 0 n.t.
eucalyptol 0/69 0/117 n.t. 0 0 n.t.
β-farnesene 0/69 0/119 n.t. 0 0 n.t.
α- and β-farnesene 0/69 0/117 n.t. 0 0 n.t.
fenchone 0/69 0/117 n.t. 0 0 n.t.
glutamic acid 0/35 0/106 n.t. 0 0 n.t.
2-heptanone 0/69 0/130 n.t. 0 0 n.t.
indole 0/69 0/117 n.t. 0 0 n.t.
isoborneol 0/69 0/117 n.t. 0 0 n.t.
isobutylamine 0/69 0/130 n.t. 0 0 n.t.
isobutyric acid n.t. 0/93 n.t. n.t. 0 n.t.
isovaleric acid n.t. 1/93 n.t. n.t. 1.1 n.t.
methionine 0/35 n.t. n.t. 0 n.t. n.t.
muscone 0/69 0/117 n.t. 0 0 n.t.
pentyl acetate 0/69 0/130 n.t. 0 0 n.t.
patchone 0/69 0/117 n.t. 0 0 n.t.
phenafleur 0/69 0/117 n.t. 0 0 n.t.
propionic acid n.t. 0/93 n.t. n.t. 0 n.t.

n.t. = not tested