Table 1.

Patient demographics and baseline characteristics from tertiary care medical center analysis of patients with CDI and chronic liver disease compared to other hospitalized patients with CDI

Variable	Chronic Liver Disease only (n=73)	C. difficile only (n=111)	C. difficile + Chronic liver disease (n=41)	P value*
Age, years (mean±SD)	58±11	64±20	60±9	0.014
Male gender – n (%)	48 (66)	44 (40)	25 (61)	0.019
Race – n (%)
African American/Black	11 (15)	25 (22.5)	9 (22)	0.26
Caucasian	41 (56)	70 (63.1)	21 (51)
Hispanic	16 (22)	11 (9.9)	9 (22)
Other	5 (7)	5 (4.5)	2 (5)
Charlson's co-morbidity Index - median (25–75 quartile)	4 (3–5)	2 (1–4)	5 (3–6)	<0.0001
Etiology of CLD – n (%)
Hepatitis B or C Virus	32 (44)	–	19 (46)	N/A
Alcohol-induced	21 (29)	–	14 (34)
Non-Alcoholic Fatty Liver Disease	20 (27)	–	8 (20)
Cirrhosis-related complications - (n%)
Hepatic encephalopathy	56 (77)	–	24 (59)	N/A
Ascites	46 (63)	–	27 (66)
Esophageal varices	43 (59)	–	22 (54)
Prior spontaneous bacterial peritonitis	20 (27)	–	10 (24)
CDI related variables
Medication use - n(%)
PPI	50 (68)	71 (64)	32 (78)
Scheduled use of narcotics	25 (34)	26 (23)	13 (32)
Continued use of non-CDI antibiotics	49 (67)	82 (74)	30 (73)
Hospital onset CDI - n(%)	–	40 (36)	16 (39)	0.46
CDI severity variables
ICU admit	–	33 (30)	13 (32)	0.81
Creatinine greater than 2.5	–	20 (19)	9 (22)	0.64
Leukocytosis greater than 15,000	–	28 (26)	8 (20)	0.41
Temperature greater than 100F	–	13 (12)	3 (7.5)	0.45
CDI outcome variables
30-day mortality	–	11 (9.9)	7 (22)	0.22
Length of hospital stay (median (25–75 quartile))		7 (4–14)	8 (5–13)	0.55

^*P value comparison between patients with C. difficile only and C. difficile + Chronic liver disease.

Tests between patients with Chronic Liver Disease only and C. difficile + Chronic liver disease were non-significant