. Author manuscript; available in PMC: 2018 Jul 30.

Published in final edited form as: Cancer. 2018 May 30;124(14):2964–2973. doi: 10.1002/cncr.31543

Table 2.

Outcomes for screening strategies with similar age to start and age to stop screening as the selected benchmark colonoscopy strategy

Modality, and Age to Start, Age to End, Interval (years)	Outcomes per 1000 40-year-olds							Efficiency Ratio^b	ER < Benchmark^c	LYG >= 90% of Benchmark	Model- Recommended Strategy^d
Modality, and Age to Start, Age to End, Interval (years)	No. of Stool tests	No. of SIGs	No. of CTCs	No. of COLs	LYG	Complications	CRC Deaths Averted^a	Efficiency Ratio^b	ER < Benchmark^c	LYG >= 90% of Benchmark	Model- Recommended Strategy^d
Colonoscopy
COL 45-75-10^e	0	0	0	5646	429	23	37	32	-	-	Yes

Stool tests
FIT 45-75-3	8038	0	0	1619	310	11	27	5	Yes	No

FIT 45-75-2	10973	0	0	1994	352	13	30	9	Yes	No

HSgFOBT 45-75-3	7405	0	0	2024	310	13	27	Dom.	-	No

FIT-DNA 45-75-5	4949	0	0	2157	333	14	29	Dom.	-	No

HSgFOBT 45-75-2	9776	0	0	2516	354	15	30	Dom.	-	No

FIT-DNA 45-75-3	6644	0	0	2640	376	16	32	Dom	-	No

FIT 45-75-1	17835	0	0	2698	403	16	34	14	Yes	Yes	Yes

HSgFOBT 45-75-1	14366	0	0	3364	403	18	34	Dom.	-	Yes

FIT-DNA 45-75-1	12019	0	0	3851	426	19	36	50	No	Yes
Flexible sigmoidoscopy
SIG 45-75-10	0	2691	0	3314	373	19	33	9	Yes	No

SIG 45-75-5	0	3865	0	3761	403	20	35	15	Yes	Yes	Yes

CT colonography
CTC 45-75-10	0	0	3045	2106	322	14	29	6	Yes	No

CTC 45-75-5	0	0	4630	2666	390	16	34	8	Yes	Yes	Yes

COL=colonoscopy, Dom.= Dominated, FIT= Fecal immunochemical test, HSgFOBT=High-sensitivity guaiac-based fecal occult blood test, FIT-DNA=Multitarget stool DNA test, SIG= Flexible sigmoidoscopy, CTC= Computed tomographic colonography, LYG= Life-years gained, CRC= Colorectal cancer, ER= Efficiency ratio

In the absence of screening, the model predicted 45 CRC Deaths.

calculated as $\frac{incremental colonoscopies w . r . t . previous efficient strategy}{incremental LYG w . r . t . previous efficient strategy}$ . It is an incremental burden-to-benefits ratio.

A strategy can only be recommended by the model if it has an efficiency ratio lower than the efficiency ratio of the benchmark strategy (colonoscopy every 10 years from ages 45 to 75 years).

A strategy is recommended by the model if it is an efficient or a near-efficient strategy with a lower burden-to-benefits ratio and at least 90% of the LYG compared to the benchmark strategy (colonoscopy screening every 10 years from ages 45 to 75 years).

This strategy was selected by the model when an efficiency ratio threshold of 40 or 45 incremental colonoscopies per LYG was applied.