hHRF-2. (A) Overall structure of hHRF-2, solved at 1.4 Å resolution. The two molecules of the asymmetric unit are coloured blue and pink. For each structure, the C-terminal tag is coloured yellow and the positions of C-terminal residues, and residues adjacent to the disordered loop, are indicated. (B) The two monomers of the hHRF dimer (blue and pink) bury a surface area of ~954 Å2 at their interface (~666 Å2 if the C-terminal His-tag is omitted from the structure). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)