Table 3. Vulnerability to QUIN-induced neurotoxicity in HD mouse models.

Vulnerability to QUIN-induced neurotoxicity is dependent on the stage of the HD phenotype in several HD mouse models of disease.

	Line	CAG	Dose	Age (months)	Result vs. wt	Phenotype	Strain	Reference
Truncated HD models	R6/1	~115	20nM	0.75	enhanced	presymptomatic	CBA/C57BL6	Hansson et al., 2001
			20nM	2	partial resistant	presymptomatic		Hansson et al., 2001
			20nM	4.5	resistant	symptomatic		Hansson et al., 2001
			20nM	5.5/9	resistant	symptomatic		Hansson et al., 1999
	R6/2	~150/200	20nM	0.75	partial resistance	presymptomatic	CBA/C57BL6	Hansson et al., 2001
			20nM	1.5	resistant	presymptomatic		Hansson et al., 2001
			20nM	2.5/3	resistant	symptomatic		Mac Gibbon et al., 2002
			KA/20mg/kg	0.75 and 2	resistant	pre/symptomatic		Morton et al., 2000
	tg46/tg100	46/100	30nM	4–78	similar	presymptomatic/symptomatic	S5L/C57BL6	Petersen et al., 2002
	N171	82	30nM	4	resistant	symptomatic	B6C3F1/J	Jarabek et al., 2004
	Shortstop	120	4nM	3,6,10	resistant	no phenotype	FVB	Slow et al., 2005; unpublished
Full length HD modes	YAC72	72	8nM	6,10	enhanced	presymptomatic	FVB	Zeron et al., 2002
	YAC128/HD55+/+	120	4nM	3	enhanced	presymptomatic		Graham et al., 2006
			6nM	12	trend resistant	symptomatic
	YAC128/HD53	120	4nM	1.5	enhanced	presymptomatic	FVB
			4nM	3	similar (trend↑)	symptomatic
			6nM	6	similar (trend↑)	symptomatic
			6nM	10	resistant	symptomatic