Table 1.
Clinical characteristics of 11 patients with NTRK-rearranged NSCLC
| Age at diagnosis, median (range) | 47.6 (25.3–86.0) |
|
| |
| Gender, n (%) | |
| Male | 6 (55) |
| Female | 5 (45) |
|
| |
| Smoking history in pack years, n (%) | |
| 0–5 | 8 (73) |
| 5–20 | 0 |
| > 20 | 3 (27) |
|
| |
| Pack years, median (range) | 0 (0–58) |
|
| |
| Stage at diagnosis (AJCC 7th edition), n (%) | |
| I | 0 |
| II | 2 (18) |
| III | 1 (9) |
| IV | 8 (73) |
|
| |
| Histology (local assessment) | |
| Adenocarcinoma | 9 (82) |
| Squamous Cell Carcinoma | 1 (9) |
| Neuroendocrine Carcinoma | 1 (9) |
|
| |
| Sites of metastasis, n | |
| Lymph nodes | 8 |
| Bone | 6 |
| Pleura or malignant effusion | 5 |
| Lung | 5 |
| Liver | 4 |
| Brain | 4 |
| Adrenal | 2 |
| Skin/soft tissue | 1 |
| Pericardium | 1 |
| Trachea | 1 |