Skip to main content
. Author manuscript; available in PMC: 2018 Dec 14.
Published in final edited form as: Dev Neurobiol. 2018 Aug 1;78(11):1026–1048. doi: 10.1002/dneu.22626

Table 3.

Somatic CNV characteristics from prior studies.

Study Methods
(Amplification,
CNV Calling)		 QC
Metrics		 Age
(years)		 Cells
Analyzed* 		Smallest
Detectable
CNV		 CNVs
per Cell* 		Deletion :
Amplification
Ratio* 		CNV Positive
Cell
Frequency*
McConnell, 201384 WGA4, CBS Reads, MAD, CS 20, 24, 26 110
(50, 19, 41)		 3.4 Mb 1.3
(2.1, 0.9, 0.6)		 2 : 1
(3:2, 8:1, 5:1)		 41%
(60%, 32%, 22%)
Gole, 2013101 MDA, CBS NR NR 6
(4, 2)		 1 Mb 6.0
(6.8, 4.5)		 2 : 3
(4:5, 1:4)		 100%
Cai, 201481 WGA4, CBS MAPD 42 19 2.2 Mb 3.4 65 : 1 68%
Knouse, 2016102 WGA4, CBS & HMM VS 48, 52, 68, 70 80
(17, 22, 21, 20)		 5 Mb 0.2
(0, 0.1, 0.1, 0.6)		 15 : 0 9%
(0%, 9%, 5%, 20%)

NR, not reported; CBS, circular binary segmentation; HMM, hidden Markov model

*

Parenthetical values indicate measurements from individual brains