Table 2.
Significantly Mutated Genes by Tumor Subtype*
| Overall (257) |
Invasive Ductal Carcinoma (221) |
Invasive Lobular Carcinoma (19) |
HER2−/HR+ (165) |
TNBC (60) |
HER2+/HR+ (24) |
HER2+/HR− (8) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P Value | % | P Value | % | P Value | % | P Value | % | P Value | % | P Value | % | P Value | % | |
| TP53 | 168.22 | 0.412 | 159.7 | 0.439 | 0.45 | 0.105 | 64.97 | 0.285 | 75.47 | 0.7 | 19.34 | 0.458 | 11.7 | 0.75 |
| PIK3CA | 54.79 | 0.245 | 44.46 | 0.231 | 6.87 | 0.474 | 51.22 | 0.321 | 0.25 | 0.0667 | 4.49 | 0.208 | 0.88 | 0.125 |
| GATA3 | 20.88 | 0.0973 | 21.85 | 0.109 | 0.1 | 0.0526 | 23.74 | 0.145 | 0 | 0 | 0.5 | 0.0417 | 0 | 0 |
| PTEN | 6.51 | 0.0467 | 4.44 | 0.0407 | 0.1 | 0.0526 | 5.22 | 0.0545 | 0.02 | 0.0167 | 0.5 | 0.0417 | 0.88 | 0.125 |
| CDH1 | 4.54 | 0.0545 | 0 | 0.0136 | 8.68 | 0.526 | 6.62 | 0.0848 | 0 | 0 | 0 | 0 | 0 | 0 |
| TGFBR2 | 2.53 | 0.035 | 1.8 | 0.0317 | 0.32 | 0.105 | 2.35 | 0.0424 | 0.02 | 0.0167 | 0.49 | 0.0417 | 0 | 0 |
| MAP3K1 | 2.17 | 0.0545 | 2.45 | 0.0588 | 0 | 0 | 3.36 | 0.0788 | 0 | 0 | 0 | 0 | 0.87 | 0.125 |
| AKT1 | 1.78 | 0.0272 | 1.64 | 0.0271 | 0.1 | 0.0526 | 2.08 | 0.0364 | 0 | 0 | 0.5 | 0.0417 | 0 | 0 |
| MAP2K4 | 1.53 | 0.0233 | 1.88 | 0.0271 | 0 | 0 | 2.39 | 0.0364 | 0 | 0 | 0 | 0 | 0 | 0 |
| RUNX1 | 1.19 | 0.0233 | 1.64 | 0.0271 | 0 | 0 | 1.32 | 0.0303 | 0 | 0 | 0.5 | 0.0417 | 0 | 0 |
*
The number represent –log10 (P Value) from a Poisson test of non-synonymous mutation rate in targeted regions against a random distribution. Genes in red significant at P<0.01 (2 or higher).