Table 1.
Serotonergic Drug List Categorized by Similar Bioactive Sites of Action. See Methods for description of pharmacologic drug categories.
| Drug Name | Category | Drug Name | Category |
|---|---|---|---|
| Amitriptyline✝ | Triple Receptor | Selegiline | MAO Inhibitor |
| Amoxapine | Triple Receptor | Tranylcypromine | MAO Inhibitor |
| Citalopram✝ | Triple Receptor | Dihydroergotamine | 5-HT1 Agonists |
| Clomipramine✝ | Triple Receptor | Eletriptan | 5-HT1 Agonists |
| Cyclobenzaprine✝ | Triple Receptor | Frovatriptan | 5-HT1 Agonists |
| Cyproheptadine | Triple Receptor | Pentazocine | 5-HT1 Agonists |
| Desipramine✝ | Triple Receptor | Rizatriptan | 5-HT1 Agonists |
| Doxepin✝ | Triple Receptor | Sumatriptan | 5-HT1 Agonists |
| Fluoxetine✝ | Triple Receptor | Zolmitriptan | 5-HT1 Agonists |
| Imipramine✝ | Triple Receptor | Almotriptan | Mixed SERT |
| Mirtazapine | Triple Receptor | Dextromethorphan✝ | Mixed SERT |
| Nortriptyline | Triple Receptor | Granisetron | Mixed SERT |
| Meperidine✝ | Triple Receptor | Lorcaserin | Mixed SERT |
| Paroxetine✝ | Triple Receptor | Naratriptan | Mixed SERT |
| Protriptyline | Triple Receptor | Trazodone | Mixed SERT |
| Sertraline | Triple Receptor | Vilazodone | Mixed SERT |
| Trimipramine | Triple Receptor | Buspirone✝ | Miscellaneous |
| Atomoxetine✝ | Duo Receptor | Carbamazepine | Miscellaneous |
| Desvenlafaxine✝ | Duo Receptor | Divalproex | Miscellaneous |
| Duloxetine✝ | Duo Receptor | Lithium | Miscellaneous |
| Escitalopram✝ | Duo Receptor | Ondansetron✝ | Miscellaneous |
| Fluvoxamine✝ | Duo Receptor | Metoclopramide | Miscellaneous |
| Levomilnacipran | Duo Receptor | Valproate | Miscellaneous |
| Maprotiline | Duo Receptor | Valproic Acid | Miscellaneous |
| Methadone✝ | Duo Receptor | Aripiprazole✝ | Atypical Antipsychotic |
| Milnacipran | Duo Receptor | Asenapine | Atypical Antipsychotic |
| Nefazodone | Duo Receptor | Brexpiprazole | Atypical Antipsychotic |
| Tramadol✝ | Duo Receptor | Clozapine✝ | Atypical Antipsychotic |
| Venlafaxine✝ | Duo Receptor | Iloperidone | Atypical Antipsychotic |
| Fentanyl✝ | MAO Inhibitor | Lurasidone | Atypical Antipsychotic |
| Isocarboxazid | MAO Inhibitor | Olanzapine | Atypical Antipsychotic |
| Linezolid | MAO Inhibitor | Paliperodine | Atypical Antipsychotic |
| Methylene Blue | MAO Inhibitor | Quetiapine | Atypical Antipsychotic |
| Phenelzine | MAO Inhibitor | Risperidone✝ | Atypical Antipsychotic |
| Rasagiline | MAO Inhibitor | Vortioxetine | Atypical Antipsychotic |
| Ziprasidone | Atypical Antipsychotic |
✝
Data taken from Flockhart P450 Drug interactions Table.42 Other listed drugs may also undergo hepatic metabolism but are less well documented.
5-HT1=5-hydroxytryptamine receptor; MAO=mon0amine oxidase; SERT=serotonin re-uptake protein