Table 3.
Univariate Spearman correlation coefficients for cerebral blood flow and clinical and demographic variables. Significant values are bolded.
| Characteristic | CKD (Rho, p-value) | Control (Rho, p-value) |
|---|---|---|
| Age (years) |
GM (−0.50, <0.001)* WM(−0.30, 0.01) WB(−0.53, <0.001) * |
GM (−0.40, 0.002) WM (−0.38, 0.003) WB (−0.51, <0.001)* |
| Race (White/Black/Asian) | GM (−0.16, 0.180) WM (−0.12, 0.331) WB (−0.14, 0.251) |
GM (0.17, 0.201) WM (0.21, 0.124) WB (0.21, 0.112) |
| Sex (male/female) | GM (0.15, 0.207) WM (0.07, 0.580) WB (0.13, 0.278) |
GM (−0.25, 0.057) WM (−0.09,0.487) WB (−0.28,0.037) |
| Age of onset (years) | GM (−0.01,0.95) WM (0.16, 0.19) WB (−0.02,0.86) |
|
| Length of disease (months) | GM (−0.23, 0.054) WM (−0.27, 0.021) WB (−0.24, 0.040) |
|
| Phosphate (mg/dl) |
GM (0.32, 0.007) WM (0.28, 0.021) WB (0.37, 0.001) |
GM (0.15, 0.257) WM (0.15, 0.266) WB(0.23, 0.084) |
| Calcium (mg/dl) | GM (−0.16, 0.187) WM (−0.10, 0.383) WB (−0.15, 0.202) |
GM (0.13, 0.334) WM (0.03, 0.812) WB (0.15, 0.259) |
| Total cholesterol (mm/dL) | GM (0.09, 0.466) WM (0.05, 0.650) WB (0.08, 0.477) |
GM (−0.06, 0.683) WM (0.03, 0.817) WB (−0.03, 0.844) |
| LDL cholesterol (mm/dL) | GM (0.08, 0.517) WM (0.07, 0.578) WB (0.08, 0.504) |
GM (−0.14, 0.297) WM (−0.03, 0.803) WB (−0.17, 0.218) |
| Triglycerides (mm/dL) | GM (0.05, 0.656) WM (0.04, 0.734) WB (0.03, 0.777) |
GM (−0.23, 0.091) WM (−0.14, 0.307) WB (−0.26, 0.060) |
| Hct (%) |
GM (−0.32, 0.005) WM (−0.21, 0.072) WB(−0.32, 0.006) |
GM (−0.44, <0.001)* WM (−0.38, 0.003) WB (−0.51, <0.001)* |
| eGFR (ml/min/1.73m2) | GM (−0.18, 0.127) WM (−0.07, 0.572) WB (−0.18, 0.120) |
GM (0.48,<0.001)* WM (0.23,0.086) WB (0.52,<0.001)* |
Note.--CKD: chronic kidney disease, Hct: hematocrit, eGFR: estimated glomerular filtration rate, LDL: low-density lipoprotein, GM: gray matter, WM: white matter, WB: whole brain.
*
P<0.001, statistical significant after Bonferroni correction.