Table 2.

AUCs and 95%CIs of stepwise selected biomarker models using five-fold Cross-validation

Model Details	Predictors	AUC (95%CI)	AUC (95%CI) with risk factors for BE
Risk factors for Barrett’s esophagus	Age, sex, ethnicity, smoking, BMI, waist-hip ratio	0.71 (0.64, 0.77)	-
All miRNAs that univariately positively predicted BE in Cytosponge application	MIR7, 10a, 30a, 145, 181a, 192, 194, 196, 199a, 199b, 215	0.87 (0.82, 0.92)	0.84 (0.79, 0.89)
Stepwise selection of miRNAs from initial model	MIR7, 30a, 181a, 192, 196, 199a	0.89 (0.84, 0.93)	0.88 (0.83, 0.93)
Above model plus TFF3	MIR7, 30a, 181a, 192, 196, 199a plus TFF3	0.92 (0.88, 0.96)	0.92 (0.88, 0.96) *
Stepwise selection of miRNAs from initial model and TFF3 (3 miRNAs and TFF3)	MIR192, 196, 199a, plus TFF3	0.93 (0.90, 0.97)	0.91 (0.87, 0.95)

^*Model did not include smoking due to failure to converge