The odds of AKI are shown on the Y-axes, with weight-adjusted acetaminophen dose (mg/kg) on the X-axes, based on multivariable analyses adjusting for age, cardiopulmonary bypass time, red cell distribution width, hypotension, nephrotoxin exposure, and Risk Adjustment for Congenital Heart Surgery (RACHS) score, which were set to their median values. Shaded areas indicate 95% confidence intervals. Left panel – Primary cohort (N=666). Right Panel – Validation cohort (N=333). AKI – Acute kidney injury.