Table 1:
Patient | Age at Presentation of Chylothorax/Sex | Cytogenetics | IgHV Status | Other prognostic markers | Treatments | Symptoms | Outcome |
---|---|---|---|---|---|---|---|
Patient 1 | 78/M | 13q deletion | Unknown | CD38 (−); Zap70 (−) | Interferon; Cladribine; Pentostatin, Cyclophosphamide and Rituximab; Bendamustine and Rituximab | Shortness of breath | Improvement × 2 years with Bendamustine and Rituxan (2 cycles) |
Patient 2 | 81/F | 11q deletion | Unknown | CD38(+) | Bendamustine and Rituxan | Shortness of breath | Marginal improvement after Bendamustine and Rituxan (3 cycles) |
Patient 3 | 77 / F | Unknown | Mutated | Unknown | Obintuzumab × 1 cycle; Idelalisib; 2400 cGy RT | Shortness of breath | Improved after 2400 cGy to thoracic duct and mediastinum |
IGHV: immunoglobulin heavy chain variable region genes; RT: radiation therapy.