. Author manuscript; available in PMC: 2020 Jan 1.

Published in final edited form as: Brain Pathol. 2018 Oct 17;29(1):126–140. doi: 10.1111/bpa.12646

Table 1:

Clinicopathologic and Molecular Features of Pilocytic Astrocytoma with Anaplasia (PA-A)

CASE	Age	Sex	Location	NF1 clinical status	History of Radiation	Temporal PA precursor	Extent of Resection	Necrosis	ALT	ATRXIHC	IDH1(R132H)	p53 IHC	BRAF Duplication	BRAF (V600E)	H3-K27M	p16 IHC	CDKN2A (FISH or NGS)	Other	Treatment for precursor	Status
1	17	M	Cerebellum	Sporadic	No	Yes	STR	Yes	POSITIVE	Lost	Negative^*	Strongly positive	Negative	Negative^*	Negative^*				observation	Dead
2	68	M	fourth ventricle	Sporadic	No	No	STR	Yes	POSITIVE	Lost	Negative	negative	Negative	Negative	Negative	loss	No mutation	NF1 p.E595Nfs^14, c.1783_1784delGA; ATRX* p.T1239fsN^*10, c.3715dupA		Dead
3	13	F	Cerebellum	Sporadic	No	No	GTR	Yes	POSITIVE	Lost	Negative^*	negative								Alive
4	12	F	cerebellum	NF1	No	No		Yes	NEGATIVE	Preserved	Negative^*	focal		Negative^*	Negative^*	Partial loss				Dead
5	22	M	Pineal	NF1	No	No	STR	No	POSITIVE	Lost				Negative^*	Negative^*					Dead
6	74	F	cerebellum	Sporadic		Yes		Yes	POSITIVE	partial	Negative^*	Strongly positive							Unknown	Dead
7	40	F	Lateral ventricle	Sporadic	Yes	Yes	STR	Yes	POSITIVE	partial	Negative^*	focal	Negative	Negative	Negative^*	loss			Irradiation	Alive
8	31	M	Spinal cord	Sporadic	Yes	Yes		Yes	POSITIVE	Lost	Negative^*	Strongly positive	Positive	Negative^*	Negative^*	loss			Irradiation	Alive
9	53	F	Cerebellum	Sporadic	Yes	Yes		Yes	POSITIVE	Lost	Negative^*	Strongly positive	Positive	Negative	positive		No mutation	H3F3A p.K27M, ATRX p. R1739X, TP53 I255S	irradiation +temozolomide	Alive
10	66	M	Cerebellum	Sporadic	Yes	Yes		No	POSITIVE	Preserved	Negative^*	focal		Negative^*	Negative^*				irradiation +chemo	Alive
11	12	M	3rd ventricle	Sporadic	No	No	STR	Yes	NEGATIVE	Preserved	Negative^*	focal	Negative	Negative^*	Negative^*	loss				Alive
12	3	M	L hemisphere	Sporadic	No	No	GTR	Yes	NEGATIVE	Preserved	Negative^*		Negative	Negative^*	Negative^*	Partial loss				Alive
13	4	M	Posterior fossa	Sporadic	No	No	STR	Yes	POSITIVE	Lost	Negative^*	Strongly positive	Negative	Negative^*	positive	Partial loss	No mutation	H3F3A p.K27M, KRAS p.Q61H, TP53 p.C275F, ATRX p.E1767, ATRX p.R2085		Dead
14	22	F	Cerebellum	Sporadic	yes	Yes		Yes	POSITIVE	lost	Negative^*	focal	Positive	Negative^*	Negative^*	loss			irradiation +chemo	Alive
15	24	M	Cerebellum	NF1	No	Yes	GTR	No	POSITIVE	lost	Negative^*	focal	Negative	Negative	Negative^*		No mutation	NF1 mutation, STAG2 p.R1207T mutation, ATRX p.Q219fs deletion, LOH	observation	Alive
16	36	M	Cerebellum	Sporadic	No	Yes	GTR	Yes	POSITIVE	lost	Negative^*	focal	Positive		Negative^*				observation	Alive
17	5	M	Cerebellum	Sporadic	No		GTR	No	NEGATIVE	Preserved	Negative^*		Positive	Negative^*		Partial loss	no deletion			Alive
18	36	F	cerebellum	Sporadic	No	No		No	POSITIVE	lost	Negative^*		Negative	Negative^*	Positive	Partial loss	no deletion			Alive
19	46	F	R temporal lobe	NF1	No	No	GTR	No	NEGATIVE	Preserved	Negative^*		Negative	Negative^*	Negative^*	preserved				Dead
20	75	M	L temporal lobe	Sporadic	No	No	GTR	No	NEGATIVE	Preserved	Negative^*		Negative	Negative	Negative^*	partial loss	no deletion			Dead
21	29	M	cerebellum	NF1	No	No	STR	No	POSITIVE	Lost	Negative^*		Negative	Negative^*	Negative^*		homozygous deletion		observation	Dead
22	10	M	3rd ventricle	Sporadic	No	No	STR	No	POSITIVE	Lost	Negative^*		Negative	Negative^*	Positive		No deletion			Dead
23	70	M	cerebellum	Sporadic	No	No		Yes	NEGATIVE	Preserved	Negative^*		Negative	Negative^*	Negative^*		homozygous deletion			Dead
24	28	M	cerebellum	Sporadic	Yes	Yes		Yes	POSITIVE		Negative^*			Negative^*	Negative^*				Irradiation	Dead
25	11	M	R frontal lobe	Sporadic	No	No	GTR	Yes	NEGATIVE	Preserved	Negative^*		Negative	Negative	Negative^*		No deletion			Alive
26	11	F	R occipital lobe	NF1	No	No	GTR	No	NEGATIVE	Preserved										Alive
27	14	M	cerebellum	Sporadic	No	No		Yes	NEGATIVE	Preserved				Negative^*	Negative^*					Dead
28	20	M	cerebellum	Sporadic	No	No		Yes	POSITIVE	lost	Negative^*		Positive	Negative^*	Negative^*		No deletion			Dead
29	27	M	cerebellum	Sporadic	Yes	Yes	GTR	Yes	POSITIVE	Lost	Negative^*		Positive	Negative^*	Negative^*		Homozygous deletion		Irradiation	Dead
30	39	F	cerebellum	Sporadic	Yes	Yes		Yes	POSITIVE	Lost	Negative^*		Positive	Negative^*	Negative^*		No deletion		Irradiation	Dead
31	46	M	L parietal lobe	NF1	No	Yes	STR	Yes	POSITIVE	Lost	Negative^*			Negative^*	Negative^*				observation	Dead
32	73	F	tectum	Sporadic	No	Yes	STR	Yes	POSITIVE	Preserved	Negative		Negative	Negative	Negative^*		No deletion		observation	Dead
33	51	M	spinal cord	Sporadic	No	No	STR	No	POSITIVE	partial	Negative^*		Negative	Negative^*	Positive		No deletion or mutation	H3F3A p.K27M, ATRX pS856del, NF1 p.L2398M, AKT1 p.R206S, BRAF p.L64I, TSC1 p.G389 fs		Dead
34	18	M	L parietal lobe	NF1		No		Yes	NEGATIVE	Preserved		focal			Negative^*	loss				Alive
35	25	F	Tectum	Sporadic	Yes	Yes		No	POSITIVE	Preserved	Negative^*	focal	Negative	Negative	Negative		No mutation	NF1 p.R816^, NF1* p.A2099D, H3F3A p.A115G	Irradiation	Alive
36	20	F	R cerebellum	Sporadic	No	No	STR	Yes	POSITIVE	Preserved	Negative^*	Strongly positive	Negative	BRAF p.D594G	Negative	loss	No mutation	NF1 p.Y1545^* NF1 p.K1440^*		Alive

NF1=neurofibromatosis type 1, STR=subtotal resection, GTR=Gross total resection, PA=pilocytic astrocytoma, ALT=alternative lenghtening of telomeres, IHC=immunohistochemistry

Evaluated by immunohistochemistry