Table 3.
Health ABC Cognitive Trajectory Analyses.
| Gene | CHR | BP Start | BP Stop | # SNPs | Test Statisticb | P Value | |
|---|---|---|---|---|---|---|---|
| Health ABC DSST cognitive trajectory analysis | CHRNA4 | 20 | 61445108 | 61463139 | 58 | 170.5 | 4.89 × 10 −3 |
| AKT2 | 19 | 45428063 | 45483105 | 52 | 176.7 | .011 | |
| GRIN1 | 9 | 139153429 | 139183029 | 26 | 82.5 | .011 | |
| PPP2R3A | 3 | 137167256 | 137349423 | 153 | 618.4 | .013 | |
| GABRR3 | 3 | 99188216 | 99236521 | 208 | 684.5 | .013 | |
| GNB1 | 1 | 1706588 | 1812355 | 53 | 170.2 | .016 | |
| ADRBK1 | 11 | 66790480 | 66810605 | 31 | 108.6 | .017 | |
| KCNQ2 | 20 | 61507985 | 61574437 | 90 | 196.1 | .019 | |
| CREB3L1 | 11 | 46255803 | 46299548 | 41 | 104.3 | .020 | |
| CYP2D6 | 22 | 40852444 | 40856827 | 50 | 177.8 | .023 | |
| CHRM4 | 11 | 46363215 | 46364683 | 13 | 44.6 | .035 | |
| GRM2 | 3 | 51716120 | 51727665 | 14 | 49.2 | .035 | |
| CHRNB4 | 15 | 76703690 | 76720642 | 107 | 275.5 | .035 | |
| SRC | 20 | 35406501 | 35467235 | 112 | 224.7 | .036 | |
| FOS | 14 | 74815283 | 74818665 | 75 | 138.8 | .040 | |
| CALML6 | 1 | 1836125 | 1838593 | 30 | 81.7 | .041 | |
| CHRNA3 | 15 | 76674705 | 76700377 | 108 | 282.6 | .041 | |
| PPP1CA | 11 | 66922227 | 66925952 | 40 | 108.8 | .045 | |
| DRD1 | 5 | 174800280 | 174803769 | 156 | 304.2 | .046 | |
| SLC12A5 | 20 | 44091244 | 44122196 | 104 | 212.7 | .049 | |
| Health ABC 3MS cognitive trajectory analysis | PLA2G3 | 22 | 29860792 | 29866469 | 77 | 393.4 | 1.61 × 10−4 |
| TRAK2 | 2 | 201950174 | 202024564 | 92 | 754.1 | 4.85 × 10−4 | |
| PLD1 | 3 | 172801311 | 173010967 | 289 | 1158.3 | 3.73 × 10−3 | |
| HTR5A | 7 | 154493478 | 154508392 | 138 | 678.9 | 3.99 × 10−3 | |
| GABRR3 | 3 | 99188216 | 99236521 | 208 | 840.8 | 4.46 × 10−3 | |
| GNG3 | 11 | 62231708 | 62233246 | 37 | 167.0 | .010 | |
| CHRM2 | 7 | 136203938 | 136352311 | 298 | 772.4 | .015 | |
| SLC6A4 | 17 | 25549031 | 25586841 | 78 | 217.3 | .023 | |
| GRM3 | 7 | 86111165 | 86332128 | 260 | 676.8 | .025 | |
| CHRNA4 | 20 | 61445108 | 61463139 | 58 | 130.4 | .025 | |
| CYP2D6 | 22 | 40852444 | 40856827 | 50 | 169.0 | .028 | |
| ITPR3 | 6 | 33697138 | 33772326 | 239 | 546.4 | .029 | |
| AKT2 | 19 | 45428063 | 45483105 | 52 | 140.4 | .031 | |
| GNAI2 | 3 | 50248650 | 50271790 | 32 | 75.7 | .040 | |
| GNG4 | 1 | 233777607 | 233880677 | 141 | 286.1 | .044 | |
| SLC38A3 | 3 | 50217695 | 50233410 | 37 | 87.1 | .046 | |
| ADCY9 | 16 | 3952652 | 4106187 | 248 | 441.6 | .050 |
Abbreviations: BP, base position; CHR, chromosome; DSST, Digit Symbol Substitution Test; Health ABC, Health, Aging, and Body Composition; 3MS, Modified Mini-Mental State Examination; SNP, single nucleotide polymorphism; VEGAS, Versatile Gene-Based Association Study.