Table 4.

Health ABC Cognitive Decline Analyses

	Gene	CHR	BP Start	BP Stop	# SNPs	Test Statistic	P Value
Health ABC DSST cognitive decline analysis	FOS	14	74815283	74818665	41	98.1	7.88 × 10−3
	CHRNA4	20	61445108	61463139	26	73.9	8.93 × 10−3
	PPP2R3A	3	137167256	137349423	75	306.0	.013
	GNB1	1	1706588	1812355	25	79.2	.013
	KCNQ2	20	61507985	61574437	46	110.7	.015
	CYP2D6	22	40852444	40856827	28	110.9	.016
	CREB3L1	11	46255803	46299548	22	58.1	.016
	GRIN1	9	139153429	139183029	14	43.1	.017
	CALML6	1	1836125	1838593	10	35.0	.019
	GABRR3	3	99188216	99236521	100	289.2	.022
	AKT2	19	45428063	45483105	27	76.7	.024
	ADRBK1	11	66790480	66810605	13	40.8	.024
	GRM2	3	51716120	51727665	7	29.1	.027
	PPP1CA	11	66922227	66925952	21	67.9	.029
	CHRNA3	15	76674705	76700377	58	157.0	.031
	SLC12A5	20	44091244	44122196	59	128.5	.032
	CHRNB4	15	76703690	76720642	59	150.5	.033
	CACNA1A	19	13178256	13478274	161	286.5	.034
Health ABC 3MS cognitive decline analysis	PLA2G3	22	29860792	29866469	43	261.7	1.72 × 10−4
	TRAK2	2	201950174	202024564	54	444.6	7.58 × 10−4
	TRAK2	2	201950174	202024564	54	444.6	7.77 × 10−4
	PLD1	3	172801311	173010967	151	583.4	4.30 × 10−3
	GABRR3	3	99188216	99236521	99	388.5	4.48 × 10−3
	HTR5A	7	154493478	154508392	58	257.9	6.09 × 10−3
	GNG3	11	62231708	62233246	15	72.2	8.78 × 10−3
	SLC6A4	17	25549031	25586841	39	120.8	.013
	GRM3	7	86111165	86332128	128	347.1	.019
	CYP2D6	22	40852444	40856827	29	110.7	.019
	ADCY9	16	3952652	4106187	128	262.7	.022
	CHRM2	7	136203938	136352311	150	374.5	.022
	ITPR3	6	33697138	33772326	118	271.6	.026
	GNG4	1	233777607	233880677	68	139.3	.046
	GNAS	20	56848189	56919645	72	143.2	.046

Abbreviations: BP, base position; CHR, chromosome; DSST, Digit Symbol Substitution Test; Health ABC, Health, Aging, and Body Composition; 3MS, Modified Mini-Mental State Examination; SNP, single nucleotide polymorphism; VEGAS, Versatile Gene-Based Association Study.