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2-F-PABA is an alternative substrate for tetrahydrofolate (THF) biosynthesis. PABA and F-PABA are substrates for dihydropteroate synthase (DHPS) in the THF biosynthesis pathway (only the terminal portion of the pathway is shown). The incorporation of PABA and PABA analogs F-PABA and PAS into dihydropteroate was quantified using a coupled assay that omitted DHFS from the reaction mixture and instead involved the direct reduction of dihydropteroate by dihydrofolate reductase (DHFR).
